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Gastrointestinal Stromal Tumors Associated with Neurofibromatosis 1 : A Single Centre Experience and Systematic Review of the Literature Including 252 Cases
المؤلفون المشاركون
Caterino, Salvatore
Antonelli, Maria Serena
Balducci, Genoveffa
Salvi, Pier Federico
Antolino, Laura
Lorenzon, Laura
المصدر
International Journal of Surgical Oncology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
The objectives of this study were (a) to report our experience regarding the association between neurofibromatosis type 1 (NF1) and gastrointestinal stromal tumors (GISTs); (b) to provide a systematic review of the literature in this field; and (c) to compare the features of NF1-associated GISTs with those reported in sporadic GISTs.
Methods.
We reported two cases of NF1-associated GISTs.
Moreover we reviewed 23 case reports/series including 252 GISTs detected in 126 NF1 patients; the data obtained from different studies were analyzed and compared to those of the sporadic GISTs undergone surgical treatment at our centre.
Results.
NF1 patients presenting with GISTs had a homogeneous M/F ratio with a mean age of 52.8 years.
NF1-associated GISTs were often reported as multiple tumors, mainly incidental, localized at the jejunum, with a mean diameter of 3.8 cm, a mean mitotic count of 3.0/50 HPF, and KIT/PDGFRα wild type.
We reported a statistical difference comparing the age and the symptoms at presentation, the tumors’ diameters and localizations, and the risk criteria of the NF1-associated GISTs comparing to those documented in sporadic GISTs.
Conclusions.
NF1-associated GISTs seem to have a distinct phenotype, specifically younger age, distal localization, small diameter, and absence of KIT/PDGRFα mutations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salvi, Pier Federico& Lorenzon, Laura& Caterino, Salvatore& Antolino, Laura& Antonelli, Maria Serena& Balducci, Genoveffa. 2013. Gastrointestinal Stromal Tumors Associated with Neurofibromatosis 1 : A Single Centre Experience and Systematic Review of the Literature Including 252 Cases. International Journal of Surgical Oncology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469034
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salvi, Pier Federico…[et al.]. Gastrointestinal Stromal Tumors Associated with Neurofibromatosis 1 : A Single Centre Experience and Systematic Review of the Literature Including 252 Cases. International Journal of Surgical Oncology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-469034
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salvi, Pier Federico& Lorenzon, Laura& Caterino, Salvatore& Antolino, Laura& Antonelli, Maria Serena& Balducci, Genoveffa. Gastrointestinal Stromal Tumors Associated with Neurofibromatosis 1 : A Single Centre Experience and Systematic Review of the Literature Including 252 Cases. International Journal of Surgical Oncology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469034
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469034
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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