Gastrointestinal Stromal Tumors Associated with Neurofibromatosis 1 : A Single Centre Experience and Systematic Review of the Literature Including 252 Cases
Joint Authors
Caterino, Salvatore
Antonelli, Maria Serena
Balducci, Genoveffa
Salvi, Pier Federico
Antolino, Laura
Lorenzon, Laura
Source
International Journal of Surgical Oncology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
The objectives of this study were (a) to report our experience regarding the association between neurofibromatosis type 1 (NF1) and gastrointestinal stromal tumors (GISTs); (b) to provide a systematic review of the literature in this field; and (c) to compare the features of NF1-associated GISTs with those reported in sporadic GISTs.
Methods.
We reported two cases of NF1-associated GISTs.
Moreover we reviewed 23 case reports/series including 252 GISTs detected in 126 NF1 patients; the data obtained from different studies were analyzed and compared to those of the sporadic GISTs undergone surgical treatment at our centre.
Results.
NF1 patients presenting with GISTs had a homogeneous M/F ratio with a mean age of 52.8 years.
NF1-associated GISTs were often reported as multiple tumors, mainly incidental, localized at the jejunum, with a mean diameter of 3.8 cm, a mean mitotic count of 3.0/50 HPF, and KIT/PDGFRα wild type.
We reported a statistical difference comparing the age and the symptoms at presentation, the tumors’ diameters and localizations, and the risk criteria of the NF1-associated GISTs comparing to those documented in sporadic GISTs.
Conclusions.
NF1-associated GISTs seem to have a distinct phenotype, specifically younger age, distal localization, small diameter, and absence of KIT/PDGRFα mutations.
American Psychological Association (APA)
Salvi, Pier Federico& Lorenzon, Laura& Caterino, Salvatore& Antolino, Laura& Antonelli, Maria Serena& Balducci, Genoveffa. 2013. Gastrointestinal Stromal Tumors Associated with Neurofibromatosis 1 : A Single Centre Experience and Systematic Review of the Literature Including 252 Cases. International Journal of Surgical Oncology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469034
Modern Language Association (MLA)
Salvi, Pier Federico…[et al.]. Gastrointestinal Stromal Tumors Associated with Neurofibromatosis 1 : A Single Centre Experience and Systematic Review of the Literature Including 252 Cases. International Journal of Surgical Oncology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-469034
American Medical Association (AMA)
Salvi, Pier Federico& Lorenzon, Laura& Caterino, Salvatore& Antolino, Laura& Antonelli, Maria Serena& Balducci, Genoveffa. Gastrointestinal Stromal Tumors Associated with Neurofibromatosis 1 : A Single Centre Experience and Systematic Review of the Literature Including 252 Cases. International Journal of Surgical Oncology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469034