![](/images/graphics-bg.png)
Combined Beta-Agonists and Corticosteroids Do Not Inhibit Extracellular Matrix Protein Production In Vitro
المؤلفون المشاركون
Burgess, Janette K.
Moir, Lyn M.
Black, Judith L.
Ge, Qi
Poniris, Maree H.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Persistent asthma is characterized by airway remodeling.
Whereas we have previously shown that neither β2-agonists nor corticosteroids inhibit extracellular matrix (ECM) protein release from airway smooth muscle (ASM) cells, the effect of their combination is unknown and this forms the rationale for the present study.
Methods.
ASM cells from people with and without asthma were stimulated with TGFβ1 (1 ng/ml) with or without budesonide (10-8 M) and formoterol (10-10 and 10-8 M), and fibronectin expression and IL-6 release were measured by ELISA.
Bronchial rings from nonasthmatic individuals were incubated with TGFβ1 (1 ng/ml) with or without the drugs, and fibronectin expression was measured using immunohistochemistry.
Results.
Budesonide stimulated fibronectin deposition, in the presence or absence of TGFβ1, and this was partially reversed by formoterol (10-8 M) in both asthmatic and nonasthmatic cells.
Budesonide and formoterol in combination failed to inhibit TGFβ-induced fibronectin in either cell type.
A similar pattern of expression of fibronectin was seen in bronchial rings.
TGFβ1-induced IL-6 release was inhibited by the combination of drugs.
Conclusion.
Current combination asthma therapies are unable to prevent or reverse remodeling events regulated by ASM cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ge, Qi& Poniris, Maree H.& Moir, Lyn M.& Black, Judith L.& Burgess, Janette K.. 2012. Combined Beta-Agonists and Corticosteroids Do Not Inhibit Extracellular Matrix Protein Production In Vitro. Journal of Allergy،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-469258
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ge, Qi…[et al.]. Combined Beta-Agonists and Corticosteroids Do Not Inhibit Extracellular Matrix Protein Production In Vitro. Journal of Allergy No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-469258
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ge, Qi& Poniris, Maree H.& Moir, Lyn M.& Black, Judith L.& Burgess, Janette K.. Combined Beta-Agonists and Corticosteroids Do Not Inhibit Extracellular Matrix Protein Production In Vitro. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-469258
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469258
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)