Immunogenicity of Simulated PCECV Postexposure Booster Doses 1, 3, and 5 Years after 2-Dose and 3-Dose Primary Rabies Vaccination in Schoolchildren
المؤلفون المشاركون
Thinyounyong, Wiravan
Khawplod, Pakamatz
Malerczyk, Claudius
Phongchamnaphai, Phana
Kamoltham, Thavatchai
Anders, Gerlind
Phraisuwan, Phran
المصدر
Advances in Preventive Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-07
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objectives.
To assess the immunogenicity of intradermal (ID) booster doses of Purified Chick Embryo Cell rabies vaccine (PCECV, Rabipur) administered to Thai schoolchildren one, three and five years after a primary ID pre-exposure (PrEP) vaccination series.
Methods.
In this follow-up study of a randomized, open-label, phase II clinical trial, two simulated post-exposure booster doses of PCECV were administered on days 0 and 3 intradermally to 703 healthy schoolchildren, one, three or five years after primary vaccination with either two or three ID doses of 0.1 mL PCECV.
Blood was drawn immediately before and 7, 14 and 365 days after the first booster dose to determine rabies virus neutralizing antibody (RVNA) concentrations.
Results.
An anamnestic response of approximately 30-fold increase in RVNA concentrations was demonstrated within 14 days after booster.
All children (100%) developed adequate RVNA concentrations above 0.5 IU/mL.
No vaccine related serious adverse events were seen in any of the vaccinees.
Conclusion.
ID rabies PrEP with PCECV is safe and immunogenic in schoolchildren and the anamnestic response to a two booster dose vaccination series was found to be adequate one, three, and five years after a two- or three-dose primary PrEP vaccination series.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kamoltham, Thavatchai& Thinyounyong, Wiravan& Khawplod, Pakamatz& Phraisuwan, Phran& Phongchamnaphai, Phana& Anders, Gerlind…[et al.]. 2011. Immunogenicity of Simulated PCECV Postexposure Booster Doses 1, 3, and 5 Years after 2-Dose and 3-Dose Primary Rabies Vaccination in Schoolchildren. Advances in Preventive Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-469272
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kamoltham, Thavatchai…[et al.]. Immunogenicity of Simulated PCECV Postexposure Booster Doses 1, 3, and 5 Years after 2-Dose and 3-Dose Primary Rabies Vaccination in Schoolchildren. Advances in Preventive Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-469272
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kamoltham, Thavatchai& Thinyounyong, Wiravan& Khawplod, Pakamatz& Phraisuwan, Phran& Phongchamnaphai, Phana& Anders, Gerlind…[et al.]. Immunogenicity of Simulated PCECV Postexposure Booster Doses 1, 3, and 5 Years after 2-Dose and 3-Dose Primary Rabies Vaccination in Schoolchildren. Advances in Preventive Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-469272
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469272
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر