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A Comparison of Epitope Repertoires Associated with Myasthenia Gravis in Humans and Nonhuman Hosts
المؤلفون المشاركون
Sette, Alessandro
Kim, Yohan
Vaughan, Kerrie
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-02
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Here we analyzed the molecular targets associated with myasthenia gravis (MG) immune responses, enabled by an immune epitope database (IEDB) inventory of approximately 600 MG-related epitopes derived from 175 references.
The vast majority of epitopes were derived from the α-subunit of human AChR suggesting that other MG-associated autoantigens should be investigated further.
Human α-AChR was mostly characterized in humans, whereas reactivity primarily to T.
californica AChR was examined in animal models.
While the fine specificity of T-cell response was similar in the two systems, substantial antibody reactivity to the C-terminus was detected in the nonhuman system, but not in humans.
Further analysis showed that the reactivity of nonhuman hosts to the C-terminus was eliminated when data were restricted to hosts tested in the context of autoimmune disease (spontaneous or induced), demonstrating that the epitopes recognized in humans and animals were shared when disease was present.
Finally, we provided data subsets relevant to particular applications, including those associated with HLA typing or restriction, sets of epitopes recognized by monoclonal antibodies, and epitopes associated with modulation of immunity or disease.
In conclusion, this analysis highlights gaps, differences, and similarities in the epitope repertoires of humans and animal models.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vaughan, Kerrie& Kim, Yohan& Sette, Alessandro. 2012. A Comparison of Epitope Repertoires Associated with Myasthenia Gravis in Humans and Nonhuman Hosts. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-469335
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vaughan, Kerrie…[et al.]. A Comparison of Epitope Repertoires Associated with Myasthenia Gravis in Humans and Nonhuman Hosts. Autoimmune Diseases No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-469335
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vaughan, Kerrie& Kim, Yohan& Sette, Alessandro. A Comparison of Epitope Repertoires Associated with Myasthenia Gravis in Humans and Nonhuman Hosts. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-469335
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469335
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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