A Comparison of Epitope Repertoires Associated with Myasthenia Gravis in Humans and Nonhuman Hosts
Joint Authors
Sette, Alessandro
Kim, Yohan
Vaughan, Kerrie
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-02
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Here we analyzed the molecular targets associated with myasthenia gravis (MG) immune responses, enabled by an immune epitope database (IEDB) inventory of approximately 600 MG-related epitopes derived from 175 references.
The vast majority of epitopes were derived from the α-subunit of human AChR suggesting that other MG-associated autoantigens should be investigated further.
Human α-AChR was mostly characterized in humans, whereas reactivity primarily to T.
californica AChR was examined in animal models.
While the fine specificity of T-cell response was similar in the two systems, substantial antibody reactivity to the C-terminus was detected in the nonhuman system, but not in humans.
Further analysis showed that the reactivity of nonhuman hosts to the C-terminus was eliminated when data were restricted to hosts tested in the context of autoimmune disease (spontaneous or induced), demonstrating that the epitopes recognized in humans and animals were shared when disease was present.
Finally, we provided data subsets relevant to particular applications, including those associated with HLA typing or restriction, sets of epitopes recognized by monoclonal antibodies, and epitopes associated with modulation of immunity or disease.
In conclusion, this analysis highlights gaps, differences, and similarities in the epitope repertoires of humans and animal models.
American Psychological Association (APA)
Vaughan, Kerrie& Kim, Yohan& Sette, Alessandro. 2012. A Comparison of Epitope Repertoires Associated with Myasthenia Gravis in Humans and Nonhuman Hosts. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-469335
Modern Language Association (MLA)
Vaughan, Kerrie…[et al.]. A Comparison of Epitope Repertoires Associated with Myasthenia Gravis in Humans and Nonhuman Hosts. Autoimmune Diseases No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-469335
American Medical Association (AMA)
Vaughan, Kerrie& Kim, Yohan& Sette, Alessandro. A Comparison of Epitope Repertoires Associated with Myasthenia Gravis in Humans and Nonhuman Hosts. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-469335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469335