Involvement of Inflammation and Adverse Vascular Remodelling in the Blood Pressure Raising Effect of Repeatedly Heated Palm Oil in Rats
المؤلفون المشاركون
Qodriyah, Hj Mohd Saad
Othman, Faizah
Jubri, Zakiah
Kamisah, Yusof
Ng, Chun-Yi
Jaarin, Kamsiah
المصدر
International Journal of Vascular Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Oil thermoxidation during deep frying generates harmful oxidative free radicals that induce inflammation and increase the risk of hypertension.
This study aimed to investigate the effect of repeatedly heated palm oil on blood pressure, aortic morphometry, and vascular cell adhesion molecule-1 (VCAM-1) expression in rats.
Male Sprague-Dawley rats were divided into five groups: control, fresh palm oil (FPO), one-time-heated palm oil (1HPO), five-time-heated palm oil (5HPO), or ten-time-heated palm oil (10HPO).
Feeding duration was six months.
Blood pressure was measured at baseline and monthly using tail-cuff method.
After six months, the rats were sacrificed and the aortic arches were dissected for morphometric and immunohistochemical analyses.
FPO group showed significantly lower blood pressure than all other groups.
Blood pressure was increased significantly in 5HPO and 10HPO groups.
The aortae of 5HPO and 10HPO groups showed significantly increased thickness and area of intima-media, circumferential wall tension, and VCAM-1 than other groups.
Elastic lamellae were disorganised and fragmented in 5HPO- and 10HPO-treated rats.
VCAM-1 expression showed a significant positive correlation with blood pressure.
In conclusion, prolonged consumption of repeatedly heated palm oil causes blood pressure elevation, adverse remodelling, and increased VCAM-1, which suggests a possible involvement of inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ng, Chun-Yi& Kamisah, Yusof& Othman, Faizah& Jubri, Zakiah& Qodriyah, Hj Mohd Saad& Jaarin, Kamsiah. 2012. Involvement of Inflammation and Adverse Vascular Remodelling in the Blood Pressure Raising Effect of Repeatedly Heated Palm Oil in Rats. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-469345
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ng, Chun-Yi…[et al.]. Involvement of Inflammation and Adverse Vascular Remodelling in the Blood Pressure Raising Effect of Repeatedly Heated Palm Oil in Rats. International Journal of Vascular Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-469345
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ng, Chun-Yi& Kamisah, Yusof& Othman, Faizah& Jubri, Zakiah& Qodriyah, Hj Mohd Saad& Jaarin, Kamsiah. Involvement of Inflammation and Adverse Vascular Remodelling in the Blood Pressure Raising Effect of Repeatedly Heated Palm Oil in Rats. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-469345
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469345
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر