Involvement of Inflammation and Adverse Vascular Remodelling in the Blood Pressure Raising Effect of Repeatedly Heated Palm Oil in Rats

Joint Authors

Qodriyah, Hj Mohd Saad
Othman, Faizah
Jubri, Zakiah
Kamisah, Yusof
Ng, Chun-Yi
Jaarin, Kamsiah

Source

International Journal of Vascular Medicine

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-06-21

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases
Medicine

Abstract EN

Oil thermoxidation during deep frying generates harmful oxidative free radicals that induce inflammation and increase the risk of hypertension.

This study aimed to investigate the effect of repeatedly heated palm oil on blood pressure, aortic morphometry, and vascular cell adhesion molecule-1 (VCAM-1) expression in rats.

Male Sprague-Dawley rats were divided into five groups: control, fresh palm oil (FPO), one-time-heated palm oil (1HPO), five-time-heated palm oil (5HPO), or ten-time-heated palm oil (10HPO).

Feeding duration was six months.

Blood pressure was measured at baseline and monthly using tail-cuff method.

After six months, the rats were sacrificed and the aortic arches were dissected for morphometric and immunohistochemical analyses.

FPO group showed significantly lower blood pressure than all other groups.

Blood pressure was increased significantly in 5HPO and 10HPO groups.

The aortae of 5HPO and 10HPO groups showed significantly increased thickness and area of intima-media, circumferential wall tension, and VCAM-1 than other groups.

Elastic lamellae were disorganised and fragmented in 5HPO- and 10HPO-treated rats.

VCAM-1 expression showed a significant positive correlation with blood pressure.

In conclusion, prolonged consumption of repeatedly heated palm oil causes blood pressure elevation, adverse remodelling, and increased VCAM-1, which suggests a possible involvement of inflammation.

American Psychological Association (APA)

Ng, Chun-Yi& Kamisah, Yusof& Othman, Faizah& Jubri, Zakiah& Qodriyah, Hj Mohd Saad& Jaarin, Kamsiah. 2012. Involvement of Inflammation and Adverse Vascular Remodelling in the Blood Pressure Raising Effect of Repeatedly Heated Palm Oil in Rats. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-469345

Modern Language Association (MLA)

Ng, Chun-Yi…[et al.]. Involvement of Inflammation and Adverse Vascular Remodelling in the Blood Pressure Raising Effect of Repeatedly Heated Palm Oil in Rats. International Journal of Vascular Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-469345

American Medical Association (AMA)

Ng, Chun-Yi& Kamisah, Yusof& Othman, Faizah& Jubri, Zakiah& Qodriyah, Hj Mohd Saad& Jaarin, Kamsiah. Involvement of Inflammation and Adverse Vascular Remodelling in the Blood Pressure Raising Effect of Repeatedly Heated Palm Oil in Rats. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-469345

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-469345