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Comparison of the In Vivo Distribution of Four Different Annexin A5 Adducts in Rhesus Monkeys
المؤلفون المشاركون
Gonzalez Trotter, Dinko
Mehmet, Huseyin
Meng, Xiangjun
Cook, Jacquelynn
Hostetler, Eric
Klimas, Michael
Reutelingsperger, Chris
Guenther, Ilonka
McQuade, Paul
Belanger, Marie-Jose
Krause, Stephen
المصدر
International Journal of Molecular Imaging
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-05-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Annexin A5 has been used for the detection of apoptotic cells, due to its ability to bind to phosphatidylserine (PS).
Four different labeled Annexin A5 adducts were evaluated in rhesus monkey, with radiolabeling achieved via 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA).
Of these adducts differing conjugation methods were employed which resulted in nonspecific radiolabeling (AxA5-I), or site-specific radiolabeling (AxA5-II).
A nonbinding variant of Annexin A5 was also evaluated (AxA5-IINBV), conjugation here was site specific.
The fourth adduct examined had both specific and nonspecific conjugation techniques employed (AxA5-IImDOTA).
Blood clearance for each adduct was comparable, while appreciable uptake was observed in kidney, liver, and spleen.
Significant differences in uptake of AxA5-I and AxA5-II were observed, as well as between AxA5-II and AxA5-IINBV.
No difference between AxA5-II and AxA5-IImDOTA was observed, suggesting that conjugating DOTA nonspecifically did not affect the in vivo biodistribution of Annexin A5.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
McQuade, Paul& Belanger, Marie-Jose& Meng, Xiangjun& Guenther, Ilonka& Krause, Stephen& Gonzalez Trotter, Dinko…[et al.]. 2011. Comparison of the In Vivo Distribution of Four Different Annexin A5 Adducts in Rhesus Monkeys. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-469513
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
McQuade, Paul…[et al.]. Comparison of the In Vivo Distribution of Four Different Annexin A5 Adducts in Rhesus Monkeys. International Journal of Molecular Imaging No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-469513
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
McQuade, Paul& Belanger, Marie-Jose& Meng, Xiangjun& Guenther, Ilonka& Krause, Stephen& Gonzalez Trotter, Dinko…[et al.]. Comparison of the In Vivo Distribution of Four Different Annexin A5 Adducts in Rhesus Monkeys. International Journal of Molecular Imaging. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-469513
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469513
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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