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Comparison of the In Vivo Distribution of Four Different Annexin A5 Adducts in Rhesus Monkeys
Joint Authors
Gonzalez Trotter, Dinko
Mehmet, Huseyin
Meng, Xiangjun
Cook, Jacquelynn
Hostetler, Eric
Klimas, Michael
Reutelingsperger, Chris
Guenther, Ilonka
McQuade, Paul
Belanger, Marie-Jose
Krause, Stephen
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Annexin A5 has been used for the detection of apoptotic cells, due to its ability to bind to phosphatidylserine (PS).
Four different labeled Annexin A5 adducts were evaluated in rhesus monkey, with radiolabeling achieved via 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA).
Of these adducts differing conjugation methods were employed which resulted in nonspecific radiolabeling (AxA5-I), or site-specific radiolabeling (AxA5-II).
A nonbinding variant of Annexin A5 was also evaluated (AxA5-IINBV), conjugation here was site specific.
The fourth adduct examined had both specific and nonspecific conjugation techniques employed (AxA5-IImDOTA).
Blood clearance for each adduct was comparable, while appreciable uptake was observed in kidney, liver, and spleen.
Significant differences in uptake of AxA5-I and AxA5-II were observed, as well as between AxA5-II and AxA5-IINBV.
No difference between AxA5-II and AxA5-IImDOTA was observed, suggesting that conjugating DOTA nonspecifically did not affect the in vivo biodistribution of Annexin A5.
American Psychological Association (APA)
McQuade, Paul& Belanger, Marie-Jose& Meng, Xiangjun& Guenther, Ilonka& Krause, Stephen& Gonzalez Trotter, Dinko…[et al.]. 2011. Comparison of the In Vivo Distribution of Four Different Annexin A5 Adducts in Rhesus Monkeys. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-469513
Modern Language Association (MLA)
McQuade, Paul…[et al.]. Comparison of the In Vivo Distribution of Four Different Annexin A5 Adducts in Rhesus Monkeys. International Journal of Molecular Imaging No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-469513
American Medical Association (AMA)
McQuade, Paul& Belanger, Marie-Jose& Meng, Xiangjun& Guenther, Ilonka& Krause, Stephen& Gonzalez Trotter, Dinko…[et al.]. Comparison of the In Vivo Distribution of Four Different Annexin A5 Adducts in Rhesus Monkeys. International Journal of Molecular Imaging. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-469513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469513