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Growth Arrest Specific Gene 6 Protein Concentration in Cerebrospinal Fluid Correlates with Relapse Severity in Multiple Sclerosis
المؤلفون المشاركون
Monaco, F.
Ranza, E.
Collimedaglia, L.
Pirisi, M.
Sola, D.
Sainaghi, P. P.
Avanzi, G. C.
Molinari, R.
Leone, Maurizio
Naldi, P.
Alciato, F.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity.
Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis.
Methods.
Sixty-five patients who underwent a spinal tap during relapse of relapsing/remitting multiple sclerosis (RR-MS)(McDonald-criteria) were studied.
Forty patients affected by noninflammatory/nonautoimmune neurological diseases served as controls.
Relapse was defined according to Schumacher criteria.
Symptoms were grouped according to Kurtzke-Functional System (FS).
Clinical characteristics of the relapse, duration, Expanded-Disability-Status Scale (EDSS) change, number of FS involved, completeness of recovery, age, steroid therapy, were categorised.
Patients were followed at 6-month intervals to assess relapse rate and EDSS progression.
Gas6 was measured (CSF, plasma) by in-house-enzyme-linked immunoassay (ELISA).
Results.
Higher CSF Gas6 concentrations were observed in relapses lasting ≤60 days (8.7 ± 3.9 ng/mL) versus >60 days (6.5 ± 2.6) or controls (6.5 ± 2.4; P=0.05), with ≤2 FS involved (8.5 ± 3.8) versus >2 FS (5.6 ± 2.5) (P<0.05) and EDSS change ≤2.5 points (8.8 ± 3.7) versus >2.5 (6.5 ± 3.5) (P=0.04).
Conversely, CSF Gas6 was not predictive of the completeness of recovery.
Plasma and CSF concentrations were not related (R2=0.0003), and neither were predictive of relapse rate or EDSS progression after first relapse.
Conclusions.
CSF concentration of Gas6 is inversely correlated with the severity of relapse in RR-MS patients but does not predict the subsequent course of the disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sainaghi, P. P.& Collimedaglia, L.& Alciato, F.& Molinari, R.& Sola, D.& Ranza, E.…[et al.]. 2013. Growth Arrest Specific Gene 6 Protein Concentration in Cerebrospinal Fluid Correlates with Relapse Severity in Multiple Sclerosis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-469593
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sainaghi, P. P.…[et al.]. Growth Arrest Specific Gene 6 Protein Concentration in Cerebrospinal Fluid Correlates with Relapse Severity in Multiple Sclerosis. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-469593
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sainaghi, P. P.& Collimedaglia, L.& Alciato, F.& Molinari, R.& Sola, D.& Ranza, E.…[et al.]. Growth Arrest Specific Gene 6 Protein Concentration in Cerebrospinal Fluid Correlates with Relapse Severity in Multiple Sclerosis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-469593
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469593
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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