The Current State of Targeted Agents in Rectal Cancer

المؤلفون المشاركون

Kim, Dae Dong
Eng, Cathy

المصدر

International Journal of Surgical Oncology

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-05-17

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Targeted biologic agents have an established role in treating metastatic colorectal cancer (CRC), and the integration of targeted therapies into the treatment of CRC has resulted in significant improvements in outcomes.

Rapidly growing insight into the molecular biology of CRC, as well as recent developments in gene sequencing and molecular diagnostics, has led to high expectations for the identification of molecular markers to be used in personalized treatment regimens.

The mechanisms of action and toxicities of targeted therapies differ from those of traditional cytotoxic chemotherapy.

Targeted therapy has raised new insight about the possibility of tailoring treatment to an individual’s disease, the assessment of drug effectiveness and toxicity, and the economics of cancer care.

This paper covers the last decade of clinical trials that have explored the toxicity and efficacy of targeted agents in locally advanced and metastatic CRC and how their role may benefit patients with rectal cancer.

Future efforts should include prospective studies of these agents in biomarker-defined subpopulations, as well as studies of novel agents that target angiogenesis, tumor-stromal interaction, and the cell signaling pathways implicated in rectal cancer.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kim, Dae Dong& Eng, Cathy. 2012. The Current State of Targeted Agents in Rectal Cancer. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-469619

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kim, Dae Dong& Eng, Cathy. The Current State of Targeted Agents in Rectal Cancer. International Journal of Surgical Oncology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-469619

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kim, Dae Dong& Eng, Cathy. The Current State of Targeted Agents in Rectal Cancer. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-469619

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-469619