The Current State of Targeted Agents in Rectal Cancer
Joint Authors
Source
International Journal of Surgical Oncology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Targeted biologic agents have an established role in treating metastatic colorectal cancer (CRC), and the integration of targeted therapies into the treatment of CRC has resulted in significant improvements in outcomes.
Rapidly growing insight into the molecular biology of CRC, as well as recent developments in gene sequencing and molecular diagnostics, has led to high expectations for the identification of molecular markers to be used in personalized treatment regimens.
The mechanisms of action and toxicities of targeted therapies differ from those of traditional cytotoxic chemotherapy.
Targeted therapy has raised new insight about the possibility of tailoring treatment to an individual’s disease, the assessment of drug effectiveness and toxicity, and the economics of cancer care.
This paper covers the last decade of clinical trials that have explored the toxicity and efficacy of targeted agents in locally advanced and metastatic CRC and how their role may benefit patients with rectal cancer.
Future efforts should include prospective studies of these agents in biomarker-defined subpopulations, as well as studies of novel agents that target angiogenesis, tumor-stromal interaction, and the cell signaling pathways implicated in rectal cancer.
American Psychological Association (APA)
Kim, Dae Dong& Eng, Cathy. 2012. The Current State of Targeted Agents in Rectal Cancer. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-469619
Modern Language Association (MLA)
Kim, Dae Dong& Eng, Cathy. The Current State of Targeted Agents in Rectal Cancer. International Journal of Surgical Oncology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-469619
American Medical Association (AMA)
Kim, Dae Dong& Eng, Cathy. The Current State of Targeted Agents in Rectal Cancer. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-469619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469619