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Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme
المؤلفون المشاركون
Yano, Hirohito
Yamada, Jitsuhiro
Shinoda, Jun
Miwa, Kazuhiro
Yokoyama, Kazutoshi
Asano, Yoshitaka
Matsuo, Masayuki
Ogawa, Shin-ichi
Iwama, Toru
Ito, Takeshi
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This research paper presents clinical outcomes of hypofractionated high-dose irradiation by intensity-modulated radiation therapy (Hypo-IMRT) with 11C-methionine positron emission tomography (MET-PET) data for the treatment of glioblastoma multiforme (GBM).
A total of 45 patients with GBM were treated with Hypo-IMRT after surgery.
Gross tumor volume (GTV) was defined as the area of enhanced lesion on MRI, including MET-PET avid region; clinical target volume (CTV) was the area with 5 mm margin surrounding the GTV; planning target volume (PTV) was the area with 15 mm margin surrounding the CTV, including MET-PET moderate region.
Hypo-IMRT was performed in 8 fractions; planning the dose for GTV was escalated to 68 Gy and that for CTV was escalated to 56 Gy, while keeping the dose delivered to the PTV at 40 Gy.
Concomitant and adjuvant TMZ chemotherapy was administered.
At a median follow-up of 18.7 months, median overall survival (OS) was 20.0 months, and median progression-free survival was 13.0 months.
The 1- and 2-year OS rates were 71.2% and 26.3%, respectively.
Adjuvant TMZ chemotherapy was significantly predictive of OS on multivariate analysis.
Late toxicity included 7 cases of Grade 3-4 radiation necrosis.
Hypo-IMRT with MET-PET data appeared to result in favorable survival outcomes for patients with GBM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miwa, Kazuhiro& Matsuo, Masayuki& Ogawa, Shin-ichi& Shinoda, Jun& Asano, Yoshitaka& Ito, Takeshi…[et al.]. 2014. Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-469642
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miwa, Kazuhiro…[et al.]. Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-469642
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miwa, Kazuhiro& Matsuo, Masayuki& Ogawa, Shin-ichi& Shinoda, Jun& Asano, Yoshitaka& Ito, Takeshi…[et al.]. Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-469642
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469642
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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