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Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme
Joint Authors
Yano, Hirohito
Yamada, Jitsuhiro
Shinoda, Jun
Miwa, Kazuhiro
Yokoyama, Kazutoshi
Asano, Yoshitaka
Matsuo, Masayuki
Ogawa, Shin-ichi
Iwama, Toru
Ito, Takeshi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This research paper presents clinical outcomes of hypofractionated high-dose irradiation by intensity-modulated radiation therapy (Hypo-IMRT) with 11C-methionine positron emission tomography (MET-PET) data for the treatment of glioblastoma multiforme (GBM).
A total of 45 patients with GBM were treated with Hypo-IMRT after surgery.
Gross tumor volume (GTV) was defined as the area of enhanced lesion on MRI, including MET-PET avid region; clinical target volume (CTV) was the area with 5 mm margin surrounding the GTV; planning target volume (PTV) was the area with 15 mm margin surrounding the CTV, including MET-PET moderate region.
Hypo-IMRT was performed in 8 fractions; planning the dose for GTV was escalated to 68 Gy and that for CTV was escalated to 56 Gy, while keeping the dose delivered to the PTV at 40 Gy.
Concomitant and adjuvant TMZ chemotherapy was administered.
At a median follow-up of 18.7 months, median overall survival (OS) was 20.0 months, and median progression-free survival was 13.0 months.
The 1- and 2-year OS rates were 71.2% and 26.3%, respectively.
Adjuvant TMZ chemotherapy was significantly predictive of OS on multivariate analysis.
Late toxicity included 7 cases of Grade 3-4 radiation necrosis.
Hypo-IMRT with MET-PET data appeared to result in favorable survival outcomes for patients with GBM.
American Psychological Association (APA)
Miwa, Kazuhiro& Matsuo, Masayuki& Ogawa, Shin-ichi& Shinoda, Jun& Asano, Yoshitaka& Ito, Takeshi…[et al.]. 2014. Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-469642
Modern Language Association (MLA)
Miwa, Kazuhiro…[et al.]. Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-469642
American Medical Association (AMA)
Miwa, Kazuhiro& Matsuo, Masayuki& Ogawa, Shin-ichi& Shinoda, Jun& Asano, Yoshitaka& Ito, Takeshi…[et al.]. Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-469642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469642