Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System
المؤلفون المشاركون
Patte-Mensah, Christine
Mensah-Nyagan, Ayikoe Guy
Boujedaini, Naoual
Venard, Christine
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Centesimal dilutions (5, 9 and 15 cH) of Gelsemium sempervirens are claimed to be capable of exerting anxiolytic and analgesic effects.
However, basic results supporting this assertion are rare, and the mechanism of action of G.
sempervirens is completely unknown.
To clarify the point, we performed a comparative analysis of the effects of dilutions 5, 9 and 15 cH of G.
sempervirens or gelsemine (the major active principle of G.
sempervirens) on allopregnanolone (3α,5α-THP) production in the rat limbic system (hippocampus and amygdala or H-A) and spinal cord (SC).
Indeed, H-A and SC are two pivotal structures controlling, respectively, anxiety and pain that are also modulated by the neurosteroid 3α,5α-THP.
At the dilution 5 cH, both G.
sempervirens and gelsemine stimulated [3H]progesterone conversion into [3H]3α,5α-THP by H-A and SC slices, and the stimulatory effect was fully (100%) reproducible in all assays.
The dilution 9 cH of G.
sempervirens or gelsemine also stimulated 3α,5α-THP formation in H-A and SC but the reproducibility rate decreased to 75%.
At 15 cH of G.
sempervirens or gelsemine, no effect was observed on 3α,5α-THP neosynthesis in H-A and SC slices.
The stimulatory action of G.
sempervirens and gelsemine (5 cH) on 3α,5α-THP production was blocked by strychnine, the selective antagonist of glycine receptors.
Altogether, these results, which constitute the first basic demonstration of cellular effects of G.
sempervirens, also offer interesting possibilities for the improvement of G.
sempervirens-based therapeutic strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Venard, Christine& Boujedaini, Naoual& Mensah-Nyagan, Ayikoe Guy& Patte-Mensah, Christine. 2011. Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-469711
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Venard, Christine…[et al.]. Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-469711
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Venard, Christine& Boujedaini, Naoual& Mensah-Nyagan, Ayikoe Guy& Patte-Mensah, Christine. Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-469711
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469711
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر