Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System
Joint Authors
Patte-Mensah, Christine
Mensah-Nyagan, Ayikoe Guy
Boujedaini, Naoual
Venard, Christine
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Centesimal dilutions (5, 9 and 15 cH) of Gelsemium sempervirens are claimed to be capable of exerting anxiolytic and analgesic effects.
However, basic results supporting this assertion are rare, and the mechanism of action of G.
sempervirens is completely unknown.
To clarify the point, we performed a comparative analysis of the effects of dilutions 5, 9 and 15 cH of G.
sempervirens or gelsemine (the major active principle of G.
sempervirens) on allopregnanolone (3α,5α-THP) production in the rat limbic system (hippocampus and amygdala or H-A) and spinal cord (SC).
Indeed, H-A and SC are two pivotal structures controlling, respectively, anxiety and pain that are also modulated by the neurosteroid 3α,5α-THP.
At the dilution 5 cH, both G.
sempervirens and gelsemine stimulated [3H]progesterone conversion into [3H]3α,5α-THP by H-A and SC slices, and the stimulatory effect was fully (100%) reproducible in all assays.
The dilution 9 cH of G.
sempervirens or gelsemine also stimulated 3α,5α-THP formation in H-A and SC but the reproducibility rate decreased to 75%.
At 15 cH of G.
sempervirens or gelsemine, no effect was observed on 3α,5α-THP neosynthesis in H-A and SC slices.
The stimulatory action of G.
sempervirens and gelsemine (5 cH) on 3α,5α-THP production was blocked by strychnine, the selective antagonist of glycine receptors.
Altogether, these results, which constitute the first basic demonstration of cellular effects of G.
sempervirens, also offer interesting possibilities for the improvement of G.
sempervirens-based therapeutic strategies.
American Psychological Association (APA)
Venard, Christine& Boujedaini, Naoual& Mensah-Nyagan, Ayikoe Guy& Patte-Mensah, Christine. 2011. Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-469711
Modern Language Association (MLA)
Venard, Christine…[et al.]. Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-469711
American Medical Association (AMA)
Venard, Christine& Boujedaini, Naoual& Mensah-Nyagan, Ayikoe Guy& Patte-Mensah, Christine. Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-469711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469711