The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity
المؤلفون المشاركون
Zhang, Zhigang
Guo, Changming
Zhang, Weiqian
Zhu, Yanzhu
Ge, Ming
Gao, Ruifeng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Arsenic trioxide (As2O3) shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL).
Unfortunately, limiting the application of this effective agent to APL patients is severe cardiotoxicity.
Resveratrol, the natural food-derived polyphenolic compound, is well known for its antioxidant properties and protects the cardiovascular system.
But the potential role of resveratrol against As2O3 in heart via nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) is unclear.
The present study evaluated the effects of pretreatment with resveratrol and As2O3 on oxidative stress and cardiac dysfunction in rat.
In the present study, resveratrol decreased As2O3-induced reactive oxygen species generation, oxidative DNA damage, and pathological alterations.
In addition, cardiac dysfunction parameters, intracellular calcium and arsenic accumulation, glutathione redox ratio, and cAMP deficiency levels were observed in As2O3-treated rats; these changes were attenuated by resveratrol.
Furthermore, resveratrol significantly prohibited the downregulation of both Nrf2 and HO-1 gene expressions that were downregulated by As2O3, whereas resveratrol did not alter As2O3-induced nitric oxide formation.
Thus, the protective role of resveratrol against As2O3-induced cardiotoxicity is implemented by the maintenance of redox homeostasis (Nrf2-HO-1 pathway) and facilitating arsenic efflux.
Our findings suggest coadministration with resveratrol, and As2O3 might provide a novel therapeutic strategy for APL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Weiqian& Guo, Changming& Gao, Ruifeng& Ge, Ming& Zhu, Yanzhu& Zhang, Zhigang. 2013. The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469726
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Weiqian…[et al.]. The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-469726
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Weiqian& Guo, Changming& Gao, Ruifeng& Ge, Ming& Zhu, Yanzhu& Zhang, Zhigang. The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469726
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469726
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر