The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity
Joint Authors
Zhang, Zhigang
Guo, Changming
Zhang, Weiqian
Zhu, Yanzhu
Ge, Ming
Gao, Ruifeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Arsenic trioxide (As2O3) shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL).
Unfortunately, limiting the application of this effective agent to APL patients is severe cardiotoxicity.
Resveratrol, the natural food-derived polyphenolic compound, is well known for its antioxidant properties and protects the cardiovascular system.
But the potential role of resveratrol against As2O3 in heart via nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) is unclear.
The present study evaluated the effects of pretreatment with resveratrol and As2O3 on oxidative stress and cardiac dysfunction in rat.
In the present study, resveratrol decreased As2O3-induced reactive oxygen species generation, oxidative DNA damage, and pathological alterations.
In addition, cardiac dysfunction parameters, intracellular calcium and arsenic accumulation, glutathione redox ratio, and cAMP deficiency levels were observed in As2O3-treated rats; these changes were attenuated by resveratrol.
Furthermore, resveratrol significantly prohibited the downregulation of both Nrf2 and HO-1 gene expressions that were downregulated by As2O3, whereas resveratrol did not alter As2O3-induced nitric oxide formation.
Thus, the protective role of resveratrol against As2O3-induced cardiotoxicity is implemented by the maintenance of redox homeostasis (Nrf2-HO-1 pathway) and facilitating arsenic efflux.
Our findings suggest coadministration with resveratrol, and As2O3 might provide a novel therapeutic strategy for APL.
American Psychological Association (APA)
Zhang, Weiqian& Guo, Changming& Gao, Ruifeng& Ge, Ming& Zhu, Yanzhu& Zhang, Zhigang. 2013. The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469726
Modern Language Association (MLA)
Zhang, Weiqian…[et al.]. The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-469726
American Medical Association (AMA)
Zhang, Weiqian& Guo, Changming& Gao, Ruifeng& Ge, Ming& Zhu, Yanzhu& Zhang, Zhigang. The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469726