New Rising Infection : Human Herpesvirus 6 Is Frequent in Myeloma Patients Undergoing Autologous Stem Cell Transplantation after Induction Therapy with Bortezomib
المؤلفون المشاركون
Horowitz, Netanel
Oren, Ilana
Held, Viki
Lavi, Noa
Zuckerman, Tsila
Avivi, Irit
Kra-Oz, Zipi
Benyamini, Noam
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Herpesvirus 6 (HHV-6) infection is a common complication during immunosuppression.
Its significance for multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT) after treatment with novel agents affecting immune system remains undetermined.
Data on 62 consecutive MM patients receiving bortezomib-dexamethasone (VD) (n=41; 66%) or thalidomide-dexamethasone (TD) (n=21, 34%) induction, together with melphalan 200 mg/m2 autograft between 01.2005 and 09.2010, were reviewed.
HHV-6 reactivation was diagnosed in patients experiencing postengraftment unexplained fever (PEUF) in the presence of any level of HHHV-6 DNA in blood.
There were no statistically significant differences in patient characteristics between the groups, excluding dexamethasone dosage, which was significantly higher in patients receiving TD.
Eight patients in TD and 18 in VD cohorts underwent viral screening for PEUF.
HHV-6 reactivation was diagnosed in 10 patients of the entire series (16%), accounting for 35% of those screened; its incidence was 19.5% (n=8) in the VD group versus 9.5% (n=2) in the TD group.
All patients recovered without sequelae.
In conclusion, HHV-6 reactivation is relatively common after ASCT, accounting for at least a third of PEUF episodes.
Further studies are warranted to investigate whether bortezomib has an impact on HHV-6 reactivation development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Horowitz, Netanel& Oren, Ilana& Lavi, Noa& Zuckerman, Tsila& Benyamini, Noam& Kra-Oz, Zipi…[et al.]. 2012. New Rising Infection : Human Herpesvirus 6 Is Frequent in Myeloma Patients Undergoing Autologous Stem Cell Transplantation after Induction Therapy with Bortezomib. Bone Marrow Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-469916
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Horowitz, Netanel…[et al.]. New Rising Infection : Human Herpesvirus 6 Is Frequent in Myeloma Patients Undergoing Autologous Stem Cell Transplantation after Induction Therapy with Bortezomib. Bone Marrow Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-469916
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Horowitz, Netanel& Oren, Ilana& Lavi, Noa& Zuckerman, Tsila& Benyamini, Noam& Kra-Oz, Zipi…[et al.]. New Rising Infection : Human Herpesvirus 6 Is Frequent in Myeloma Patients Undergoing Autologous Stem Cell Transplantation after Induction Therapy with Bortezomib. Bone Marrow Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-469916
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469916
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر