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New Rising Infection : Human Herpesvirus 6 Is Frequent in Myeloma Patients Undergoing Autologous Stem Cell Transplantation after Induction Therapy with Bortezomib
Joint Authors
Horowitz, Netanel
Oren, Ilana
Held, Viki
Lavi, Noa
Zuckerman, Tsila
Avivi, Irit
Kra-Oz, Zipi
Benyamini, Noam
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Herpesvirus 6 (HHV-6) infection is a common complication during immunosuppression.
Its significance for multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT) after treatment with novel agents affecting immune system remains undetermined.
Data on 62 consecutive MM patients receiving bortezomib-dexamethasone (VD) (n=41; 66%) or thalidomide-dexamethasone (TD) (n=21, 34%) induction, together with melphalan 200 mg/m2 autograft between 01.2005 and 09.2010, were reviewed.
HHV-6 reactivation was diagnosed in patients experiencing postengraftment unexplained fever (PEUF) in the presence of any level of HHHV-6 DNA in blood.
There were no statistically significant differences in patient characteristics between the groups, excluding dexamethasone dosage, which was significantly higher in patients receiving TD.
Eight patients in TD and 18 in VD cohorts underwent viral screening for PEUF.
HHV-6 reactivation was diagnosed in 10 patients of the entire series (16%), accounting for 35% of those screened; its incidence was 19.5% (n=8) in the VD group versus 9.5% (n=2) in the TD group.
All patients recovered without sequelae.
In conclusion, HHV-6 reactivation is relatively common after ASCT, accounting for at least a third of PEUF episodes.
Further studies are warranted to investigate whether bortezomib has an impact on HHV-6 reactivation development.
American Psychological Association (APA)
Horowitz, Netanel& Oren, Ilana& Lavi, Noa& Zuckerman, Tsila& Benyamini, Noam& Kra-Oz, Zipi…[et al.]. 2012. New Rising Infection : Human Herpesvirus 6 Is Frequent in Myeloma Patients Undergoing Autologous Stem Cell Transplantation after Induction Therapy with Bortezomib. Bone Marrow Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-469916
Modern Language Association (MLA)
Horowitz, Netanel…[et al.]. New Rising Infection : Human Herpesvirus 6 Is Frequent in Myeloma Patients Undergoing Autologous Stem Cell Transplantation after Induction Therapy with Bortezomib. Bone Marrow Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-469916
American Medical Association (AMA)
Horowitz, Netanel& Oren, Ilana& Lavi, Noa& Zuckerman, Tsila& Benyamini, Noam& Kra-Oz, Zipi…[et al.]. New Rising Infection : Human Herpesvirus 6 Is Frequent in Myeloma Patients Undergoing Autologous Stem Cell Transplantation after Induction Therapy with Bortezomib. Bone Marrow Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-469916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469916