A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming
المؤلفون المشاركون
Wall, D. J. N.
Evans, John J.
Wilkinson, T. M.
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
An acute response of LH to a stimulatory pulse of GnRH is modelled as a result of a pathway (Pathway I) that consists of two compartments including a single (rate limiting) intermediate.
In addition, a second pathway (Pathway II) was added, consisting of an intermediate transcription factor and subsequently a synthesised protein.
Pathway II had a delayed effect on LH release due to the time taken to produce the intermediate protein.
The model included synergism between these two pathways, which yielded an augmented response.
The model accounts for a number of observations, including GnRH self-priming and the biphasic pattern of LH response.
The same model was used to fit the data of the LH response when gonadotrophs responded to the addition of oxytocin in the response with a shoulder on the profile.
Pathway I is able to be conceptualised as the basic Ca2+-mediated pathway.
Pathway II contains features characteristic of the cAMP-mediated pathway.
Thus, we have provided an explanation for details of the nature of the profile of LH secretion and additionally enabled incorporation of cAMP in an integrating model.
The study investigated the possibility of two interacting pathways being at the basis of both the shoulder on the LH surges and self-priming, and the model illustrates that this appears to be highly likely.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Evans, John J.& Wilkinson, T. M.& Wall, D. J. N.. 2013. A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-469950
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Evans, John J.…[et al.]. A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming. International Journal of Endocrinology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-469950
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Evans, John J.& Wilkinson, T. M.& Wall, D. J. N.. A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-469950
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469950
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر