A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming
Joint Authors
Wall, D. J. N.
Evans, John J.
Wilkinson, T. M.
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
An acute response of LH to a stimulatory pulse of GnRH is modelled as a result of a pathway (Pathway I) that consists of two compartments including a single (rate limiting) intermediate.
In addition, a second pathway (Pathway II) was added, consisting of an intermediate transcription factor and subsequently a synthesised protein.
Pathway II had a delayed effect on LH release due to the time taken to produce the intermediate protein.
The model included synergism between these two pathways, which yielded an augmented response.
The model accounts for a number of observations, including GnRH self-priming and the biphasic pattern of LH response.
The same model was used to fit the data of the LH response when gonadotrophs responded to the addition of oxytocin in the response with a shoulder on the profile.
Pathway I is able to be conceptualised as the basic Ca2+-mediated pathway.
Pathway II contains features characteristic of the cAMP-mediated pathway.
Thus, we have provided an explanation for details of the nature of the profile of LH secretion and additionally enabled incorporation of cAMP in an integrating model.
The study investigated the possibility of two interacting pathways being at the basis of both the shoulder on the LH surges and self-priming, and the model illustrates that this appears to be highly likely.
American Psychological Association (APA)
Evans, John J.& Wilkinson, T. M.& Wall, D. J. N.. 2013. A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-469950
Modern Language Association (MLA)
Evans, John J.…[et al.]. A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming. International Journal of Endocrinology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-469950
American Medical Association (AMA)
Evans, John J.& Wilkinson, T. M.& Wall, D. J. N.. A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-469950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469950