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Extracts of Tripterygium wilfordii Hook F in the Treatment of Rheumatoid Arthritis : A Systemic Review and Meta-Analysis of Randomised Controlled Trials
المؤلفون المشاركون
Hu, Yonghong
Liu, Yafei
Tu, Shenghao
Gao, Weina
Liu, Peilin
Wang, Yu
Dong, Hui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Clinical trials have reported the effects of Tripterygium wilfordii Hook F (TwHF) extracts (TEs) in the treatment of rheumatoid arthritis (RA); however, the results have been inconsistent.
This meta-analysis is aimed to assess the safety of TEs and their effects on the treatment of RA.
Randomised controlled trials (RCTs) comparing the effects of TEs and placebo (PBO) or disease-modifying antirheumatic drugs (DMARDs) in patients with RA were included.
Weighted mean differences (MDs) were calculated for net changes by employing fixed-effect or random-effects models.
After filtering, ten RCTs (involving 733 participants) were included in this study.
The methodological quality of these studies was generally low.
Compared with DMARDs, TEs alone produced a mild increase in grip strength (GS) (P=0.02; standard mean difference (SMD) = 0.81; 95% confidence interval (CI): 0.14 to 1.48).
The most common adverse effects (AEs) of TEs were gastrointestinal discomfort, menstruation disorders, and amenorrhea.
In conclusion, TEs, as a sort of “herbal DMARD,” could be as effective as synthetic DMARDs in the treatment of RA.
However, the efficacy of TEs in treating RA should be further estimated with better designed, fully powered, confirmatory RCTs that apply the American College of Rheumatology (ACR) improvement criteria to evaluate their outcomes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yafei& Tu, Shenghao& Gao, Weina& Wang, Yu& Liu, Peilin& Hu, Yonghong…[et al.]. 2013. Extracts of Tripterygium wilfordii Hook F in the Treatment of Rheumatoid Arthritis : A Systemic Review and Meta-Analysis of Randomised Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-469987
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yafei…[et al.]. Extracts of Tripterygium wilfordii Hook F in the Treatment of Rheumatoid Arthritis : A Systemic Review and Meta-Analysis of Randomised Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-469987
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yafei& Tu, Shenghao& Gao, Weina& Wang, Yu& Liu, Peilin& Hu, Yonghong…[et al.]. Extracts of Tripterygium wilfordii Hook F in the Treatment of Rheumatoid Arthritis : A Systemic Review and Meta-Analysis of Randomised Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-469987
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469987
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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