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Extracts of Tripterygium wilfordii Hook F in the Treatment of Rheumatoid Arthritis : A Systemic Review and Meta-Analysis of Randomised Controlled Trials
Joint Authors
Hu, Yonghong
Liu, Yafei
Tu, Shenghao
Gao, Weina
Liu, Peilin
Wang, Yu
Dong, Hui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Clinical trials have reported the effects of Tripterygium wilfordii Hook F (TwHF) extracts (TEs) in the treatment of rheumatoid arthritis (RA); however, the results have been inconsistent.
This meta-analysis is aimed to assess the safety of TEs and their effects on the treatment of RA.
Randomised controlled trials (RCTs) comparing the effects of TEs and placebo (PBO) or disease-modifying antirheumatic drugs (DMARDs) in patients with RA were included.
Weighted mean differences (MDs) were calculated for net changes by employing fixed-effect or random-effects models.
After filtering, ten RCTs (involving 733 participants) were included in this study.
The methodological quality of these studies was generally low.
Compared with DMARDs, TEs alone produced a mild increase in grip strength (GS) (P=0.02; standard mean difference (SMD) = 0.81; 95% confidence interval (CI): 0.14 to 1.48).
The most common adverse effects (AEs) of TEs were gastrointestinal discomfort, menstruation disorders, and amenorrhea.
In conclusion, TEs, as a sort of “herbal DMARD,” could be as effective as synthetic DMARDs in the treatment of RA.
However, the efficacy of TEs in treating RA should be further estimated with better designed, fully powered, confirmatory RCTs that apply the American College of Rheumatology (ACR) improvement criteria to evaluate their outcomes.
American Psychological Association (APA)
Liu, Yafei& Tu, Shenghao& Gao, Weina& Wang, Yu& Liu, Peilin& Hu, Yonghong…[et al.]. 2013. Extracts of Tripterygium wilfordii Hook F in the Treatment of Rheumatoid Arthritis : A Systemic Review and Meta-Analysis of Randomised Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-469987
Modern Language Association (MLA)
Liu, Yafei…[et al.]. Extracts of Tripterygium wilfordii Hook F in the Treatment of Rheumatoid Arthritis : A Systemic Review and Meta-Analysis of Randomised Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-469987
American Medical Association (AMA)
Liu, Yafei& Tu, Shenghao& Gao, Weina& Wang, Yu& Liu, Peilin& Hu, Yonghong…[et al.]. Extracts of Tripterygium wilfordii Hook F in the Treatment of Rheumatoid Arthritis : A Systemic Review and Meta-Analysis of Randomised Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-469987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469987