Protein Glycation in Diabetes as Determined by Mass Spectrometry
المؤلفون المشاركون
Annunziata, Lapolla
Molin, Laura
Traldi, Pietro
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Diabetes is a common endocrine disorder characterized by hyperglycemia leading to nonenzymatic glycation of proteins, responsible for chronic complications.
The development of mass spectrometric techniques able to give highly specific and reliable results in proteome field is of wide interest for physicians, giving them new tools to monitor the disease progression and the possible complications related to diabetes, as well as the effectiveness of therapeutic treatments.
This paper reports and discusses some of the data pertaining protein glycation in diabetic subjects obtained by matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS).
The preliminary studies carried out by in vitro protein glycation experiments show clear differences in molecular weight of glycated and unglycated proteins.
Then, the attention was focused on plasma proteins human serum albumin (HSA) and immunoglobulin G (IgG).
Enzymatic degradation products of in vitro glycated HSA were studied in order to simulate the in vivo enzymatic digestion of glycated species by the immunological system leading to the highly reactive advanced glycation end-products (AGEs) peptides.
Further studies led to the evaluation of glycated Apo A-I and glycated haemoglobin levels.
A different MALDI approach was employed for the identification of markers of disease in urine samples of healthy, diabetic, nephropathic, and diabetic-nephropathic subjects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Annunziata, Lapolla& Molin, Laura& Traldi, Pietro. 2013. Protein Glycation in Diabetes as Determined by Mass Spectrometry. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-470030
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Annunziata, Lapolla…[et al.]. Protein Glycation in Diabetes as Determined by Mass Spectrometry. International Journal of Endocrinology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-470030
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Annunziata, Lapolla& Molin, Laura& Traldi, Pietro. Protein Glycation in Diabetes as Determined by Mass Spectrometry. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-470030
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470030
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر