Anti-Ro52 Antibodies and Interstitial Lung Disease in Connective Tissue Diseases Excluding Scleroderma
المؤلفون المشاركون
Almeida, Isabel
Vasconcelos, Carlos
Ferreira, João Pedro
Marinho, António
Cerveira, Conceição
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-27
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Introduction.
The presence of anti-Ro52 antibodies has been reported in a wide variety of autoimmune diseases, particularly in myositis, scleroderma, and autoimmune liver diseases.
Clinical significance of anti-Ro52 antibodies remains controversial, and studies are lacking for clarifying the association of anti-Ro52 with interstitial lung disease (ILD) in connective tissue diseases (CTD).
Objectives.
To determine if anti-Ro52 antibodies are associated with ILD in CTD other than scleroderma.
Methods.
Single-center, retrospective study based on immunoblotting panel analysis and patients clinical records.
Results.
In our connective tissue disease cohort, 162 patients had immunoblotting panels with anti-Ro52 reactivity analysis, 41 (25,3%) had inclusion criteria.
Among the 41 selected sera, 85.4% (n=35) had anti-Ro52 reactivity.
The prevalence of ILD in the positive anti-Ro52 antibodies was 71.4% (n=25), and 16.7% (n=1) in the negative anti-Ro52 group (P=0.018).
Overall sensitivity (96.2%), specificity (83.3%), positive (71.4%) and negative (83.3%) predictive values of anti-Ro52 antibodies to determine ILD in CTD is detailed in this study.
Conclusion.
Ro52 autoantibodies are associated with ILD in CTD excluding scleroderma.
We suggest that the presence of anti-Ro52 reactivity in CTD should increase the clinician curiosity for the search of ILD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ferreira, João Pedro& Almeida, Isabel& Marinho, António& Cerveira, Conceição& Vasconcelos, Carlos. 2012. Anti-Ro52 Antibodies and Interstitial Lung Disease in Connective Tissue Diseases Excluding Scleroderma. ISRN Rheumatology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-470333
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ferreira, João Pedro…[et al.]. Anti-Ro52 Antibodies and Interstitial Lung Disease in Connective Tissue Diseases Excluding Scleroderma. ISRN Rheumatology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-470333
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ferreira, João Pedro& Almeida, Isabel& Marinho, António& Cerveira, Conceição& Vasconcelos, Carlos. Anti-Ro52 Antibodies and Interstitial Lung Disease in Connective Tissue Diseases Excluding Scleroderma. ISRN Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-470333
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470333
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر