Anti-Ro52 Antibodies and Interstitial Lung Disease in Connective Tissue Diseases Excluding Scleroderma

Abstract EN

Introduction.

The presence of anti-Ro52 antibodies has been reported in a wide variety of autoimmune diseases, particularly in myositis, scleroderma, and autoimmune liver diseases.

Clinical significance of anti-Ro52 antibodies remains controversial, and studies are lacking for clarifying the association of anti-Ro52 with interstitial lung disease (ILD) in connective tissue diseases (CTD).

Objectives.

To determine if anti-Ro52 antibodies are associated with ILD in CTD other than scleroderma.

Methods.

Single-center, retrospective study based on immunoblotting panel analysis and patients clinical records.

Results.

In our connective tissue disease cohort, 162 patients had immunoblotting panels with anti-Ro52 reactivity analysis, 41 (25,3%) had inclusion criteria.

Among the 41 selected sera, 85.4% (n=35) had anti-Ro52 reactivity.

The prevalence of ILD in the positive anti-Ro52 antibodies was 71.4% (n=25), and 16.7% (n=1) in the negative anti-Ro52 group (P=0.018).

Overall sensitivity (96.2%), specificity (83.3%), positive (71.4%) and negative (83.3%) predictive values of anti-Ro52 antibodies to determine ILD in CTD is detailed in this study.

Conclusion.

Ro52 autoantibodies are associated with ILD in CTD excluding scleroderma.

We suggest that the presence of anti-Ro52 reactivity in CTD should increase the clinician curiosity for the search of ILD.