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Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress
المؤلفون المشاركون
Zilmer, K.
Zilmer, Mihkel
Kaur, S.
Leping, V.
المصدر
Dermatology Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Research has confirmed the involvement of oxidative stress (OxS) in allergic contact dermatitis whilst other inflammation-related biomarkers have been less studied.
Objective.
To evaluate systemic levels of selected inflammatory markers, OxS indices and adipokines as well as their associations in allergic contact dermatitis.
Methods.
In 40 patients, interleukin- (IL-) 6, monocyte chemoattractant protein (MCP-1), and IL-10 levels were measured in sera with the Evidence Investigator Cytokine & Growth factors High-Sensitivity Array, total peroxide concentration (TPX) and total antioxidant capacity (TAC) by means of spectrophotometry, and the plasma concentrations of adiponectin and leptin by the quantitative sandwich enzyme immunoassay technique.
Results.
TNF-α level (P < 0.01) and TPX (P < 0.0001) were increased whilst IL-10 (P < 0.05) and TAC (P < 0.0001) were decreased in the patients as compared to controls.
Correlation and multiple linear regression analysis identified both, TPX and TAC (inversely), as possible independent markers for evaluating allergic contact dermatitis.
Adiponectin level in patients was increased (P < 0.0001), but neither adiponectin nor leptin correlated significantly with the biomarkers of inflammation or OxS.
Conclusion.
OxS parameters, especially TPX and OSI, reflect the degree of systemic inflammation associated with allergic contact dermatitis in the best way.
The relation between OxS and adiponectin level warrants further studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kaur, S.& Zilmer, K.& Leping, V.& Zilmer, Mihkel. 2014. Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress. Dermatology Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-470362
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kaur, S.…[et al.]. Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress. Dermatology Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-470362
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kaur, S.& Zilmer, K.& Leping, V.& Zilmer, Mihkel. Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress. Dermatology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-470362
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470362
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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