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Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress
Joint Authors
Zilmer, K.
Zilmer, Mihkel
Kaur, S.
Leping, V.
Source
Dermatology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Research has confirmed the involvement of oxidative stress (OxS) in allergic contact dermatitis whilst other inflammation-related biomarkers have been less studied.
Objective.
To evaluate systemic levels of selected inflammatory markers, OxS indices and adipokines as well as their associations in allergic contact dermatitis.
Methods.
In 40 patients, interleukin- (IL-) 6, monocyte chemoattractant protein (MCP-1), and IL-10 levels were measured in sera with the Evidence Investigator Cytokine & Growth factors High-Sensitivity Array, total peroxide concentration (TPX) and total antioxidant capacity (TAC) by means of spectrophotometry, and the plasma concentrations of adiponectin and leptin by the quantitative sandwich enzyme immunoassay technique.
Results.
TNF-α level (P < 0.01) and TPX (P < 0.0001) were increased whilst IL-10 (P < 0.05) and TAC (P < 0.0001) were decreased in the patients as compared to controls.
Correlation and multiple linear regression analysis identified both, TPX and TAC (inversely), as possible independent markers for evaluating allergic contact dermatitis.
Adiponectin level in patients was increased (P < 0.0001), but neither adiponectin nor leptin correlated significantly with the biomarkers of inflammation or OxS.
Conclusion.
OxS parameters, especially TPX and OSI, reflect the degree of systemic inflammation associated with allergic contact dermatitis in the best way.
The relation between OxS and adiponectin level warrants further studies.
American Psychological Association (APA)
Kaur, S.& Zilmer, K.& Leping, V.& Zilmer, Mihkel. 2014. Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress. Dermatology Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-470362
Modern Language Association (MLA)
Kaur, S.…[et al.]. Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress. Dermatology Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-470362
American Medical Association (AMA)
Kaur, S.& Zilmer, K.& Leping, V.& Zilmer, Mihkel. Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress. Dermatology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-470362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470362