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Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats
المؤلفون المشاركون
Hassandarvish, Pouya
Tayyab, Saad
Abdulla, Mahmood Ameen
Ismail, Salmah
Rahim, Nurhidayah Ab.
Golbabapour, Shahram
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Herbal medicines appeared promising in prevention of many diseases.
This study was conducted to investigate the gastroprotective effect of Curcuma xanthorrhiza leaf in the rats induced gastric ulcer by ethanol.
Normal and ulcer control received carboxymethycellulose (5 mL/kg) orally, positive control was administered with 20 mg/kg omeprazole (reference drug) and 2 groups were received 250 mg/kg and 500 mg/kg of the leaf extract, respectively.
To induce of gastric ulcers formation, ethanol (5 mL/kg) was given orally to all groups except normal control.
Gross ulcer areas, histology, and amount of prostaglandin E2, superoxide dismutase and malondialdehyde were assessed to determine the potentiality of extract in prevention against gastric ulcers.
Oral administration of extract showed significant gastric protection effect as the ulcer areas was remarkably decreased.
Histology observation showed less edema and leucocytes infiltration as compared with the ulcer control which exhibited severe gastric mucosa injury.
Furthermore, the leaf extract elevated the mucus weight, level of prostaglandin E2 and superoxide dismutase.
The extract also reduced malondialdehyde amount significantly.
Results showed leaf extract of Curcuma xanthorrhiza can enhanced the gastric protection and sustained the integrity of gastric mucosa structure.
Acute toxicity test did not showed any sign of toxicity (2 g/kg and 5 g/kg).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rahim, Nurhidayah Ab.& Hassandarvish, Pouya& Golbabapour, Shahram& Ismail, Salmah& Tayyab, Saad& Abdulla, Mahmood Ameen. 2014. Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-470448
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rahim, Nurhidayah Ab.…[et al.]. Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-470448
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rahim, Nurhidayah Ab.& Hassandarvish, Pouya& Golbabapour, Shahram& Ismail, Salmah& Tayyab, Saad& Abdulla, Mahmood Ameen. Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-470448
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470448
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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