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Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats
Joint Authors
Hassandarvish, Pouya
Tayyab, Saad
Abdulla, Mahmood Ameen
Ismail, Salmah
Rahim, Nurhidayah Ab.
Golbabapour, Shahram
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Herbal medicines appeared promising in prevention of many diseases.
This study was conducted to investigate the gastroprotective effect of Curcuma xanthorrhiza leaf in the rats induced gastric ulcer by ethanol.
Normal and ulcer control received carboxymethycellulose (5 mL/kg) orally, positive control was administered with 20 mg/kg omeprazole (reference drug) and 2 groups were received 250 mg/kg and 500 mg/kg of the leaf extract, respectively.
To induce of gastric ulcers formation, ethanol (5 mL/kg) was given orally to all groups except normal control.
Gross ulcer areas, histology, and amount of prostaglandin E2, superoxide dismutase and malondialdehyde were assessed to determine the potentiality of extract in prevention against gastric ulcers.
Oral administration of extract showed significant gastric protection effect as the ulcer areas was remarkably decreased.
Histology observation showed less edema and leucocytes infiltration as compared with the ulcer control which exhibited severe gastric mucosa injury.
Furthermore, the leaf extract elevated the mucus weight, level of prostaglandin E2 and superoxide dismutase.
The extract also reduced malondialdehyde amount significantly.
Results showed leaf extract of Curcuma xanthorrhiza can enhanced the gastric protection and sustained the integrity of gastric mucosa structure.
Acute toxicity test did not showed any sign of toxicity (2 g/kg and 5 g/kg).
American Psychological Association (APA)
Rahim, Nurhidayah Ab.& Hassandarvish, Pouya& Golbabapour, Shahram& Ismail, Salmah& Tayyab, Saad& Abdulla, Mahmood Ameen. 2014. Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-470448
Modern Language Association (MLA)
Rahim, Nurhidayah Ab.…[et al.]. Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-470448
American Medical Association (AMA)
Rahim, Nurhidayah Ab.& Hassandarvish, Pouya& Golbabapour, Shahram& Ismail, Salmah& Tayyab, Saad& Abdulla, Mahmood Ameen. Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-470448
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470448