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Evidence of Stage- and Age-Related Heterogeneity of Non-HLA SNPs and Risk of Islet Autoimmunity and Type 1 Diabetes : The Diabetes Autoimmunity Study in the Young
المؤلفون المشاركون
Rewers, Marian
Lamb, Molly M.
Wong, Randall
Norris, Jill M.
Kroehl, Miranda
Steck, Andrea K.
Frederiksen, Brittni N.
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Previously, we examined 20 non-HLA SNPs for association with islet autoimmunity (IA) and/or progression to type 1 diabetes (T1D).
Our objective was to investigate fourteen additional non-HLA T1D candidate SNPs for stage- and age-related heterogeneity in the etiology of T1D.
Of 1634 non-Hispanic white DAISY children genotyped, 132 developed IA (positive for GAD, insulin, or IA-2 autoantibodies at two or more consecutive visits); 50 IA positive children progressed to T1D.
Cox regression was used to analyze risk of IA and progression to T1D in IA positive children.
Restricted cubic splines were used to model SNPs when there was evidence that risk was not constant with age.
C1QTNF6 (rs229541) predicted increased IA risk (HR: 1.57, CI: 1.20–2.05) but not progression to T1D (HR: 1.13, CI: 0.75–1.71).
SNP (rs10517086) appears to exhibit an age-related effect on risk of IA, with increased risk before age 2 years (age 2 HR: 1.67, CI: 1.08–2.56) but not older ages (age 4 HR: 0.84, CI: 0.43–1.62).
C1QTNF6 (rs229541), SNP (rs10517086), and UBASH3A (rs3788013) were associated with development of T1D.
This prospective investigation of non-HLA T1D candidate loci shows that some SNPs may exhibit stage- and age-related heterogeneity in the etiology of T1D.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Frederiksen, Brittni N.& Steck, Andrea K.& Kroehl, Miranda& Lamb, Molly M.& Wong, Randall& Rewers, Marian…[et al.]. 2013. Evidence of Stage- and Age-Related Heterogeneity of Non-HLA SNPs and Risk of Islet Autoimmunity and Type 1 Diabetes : The Diabetes Autoimmunity Study in the Young. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470561
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Frederiksen, Brittni N.…[et al.]. Evidence of Stage- and Age-Related Heterogeneity of Non-HLA SNPs and Risk of Islet Autoimmunity and Type 1 Diabetes : The Diabetes Autoimmunity Study in the Young. Clinical and Developmental Immunology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-470561
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Frederiksen, Brittni N.& Steck, Andrea K.& Kroehl, Miranda& Lamb, Molly M.& Wong, Randall& Rewers, Marian…[et al.]. Evidence of Stage- and Age-Related Heterogeneity of Non-HLA SNPs and Risk of Islet Autoimmunity and Type 1 Diabetes : The Diabetes Autoimmunity Study in the Young. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470561
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470561
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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