Evidence of Stage- and Age-Related Heterogeneity of Non-HLA SNPs and Risk of Islet Autoimmunity and Type 1 Diabetes : The Diabetes Autoimmunity Study in the Young
Joint Authors
Rewers, Marian
Lamb, Molly M.
Wong, Randall
Norris, Jill M.
Kroehl, Miranda
Steck, Andrea K.
Frederiksen, Brittni N.
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Previously, we examined 20 non-HLA SNPs for association with islet autoimmunity (IA) and/or progression to type 1 diabetes (T1D).
Our objective was to investigate fourteen additional non-HLA T1D candidate SNPs for stage- and age-related heterogeneity in the etiology of T1D.
Of 1634 non-Hispanic white DAISY children genotyped, 132 developed IA (positive for GAD, insulin, or IA-2 autoantibodies at two or more consecutive visits); 50 IA positive children progressed to T1D.
Cox regression was used to analyze risk of IA and progression to T1D in IA positive children.
Restricted cubic splines were used to model SNPs when there was evidence that risk was not constant with age.
C1QTNF6 (rs229541) predicted increased IA risk (HR: 1.57, CI: 1.20–2.05) but not progression to T1D (HR: 1.13, CI: 0.75–1.71).
SNP (rs10517086) appears to exhibit an age-related effect on risk of IA, with increased risk before age 2 years (age 2 HR: 1.67, CI: 1.08–2.56) but not older ages (age 4 HR: 0.84, CI: 0.43–1.62).
C1QTNF6 (rs229541), SNP (rs10517086), and UBASH3A (rs3788013) were associated with development of T1D.
This prospective investigation of non-HLA T1D candidate loci shows that some SNPs may exhibit stage- and age-related heterogeneity in the etiology of T1D.
American Psychological Association (APA)
Frederiksen, Brittni N.& Steck, Andrea K.& Kroehl, Miranda& Lamb, Molly M.& Wong, Randall& Rewers, Marian…[et al.]. 2013. Evidence of Stage- and Age-Related Heterogeneity of Non-HLA SNPs and Risk of Islet Autoimmunity and Type 1 Diabetes : The Diabetes Autoimmunity Study in the Young. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470561
Modern Language Association (MLA)
Frederiksen, Brittni N.…[et al.]. Evidence of Stage- and Age-Related Heterogeneity of Non-HLA SNPs and Risk of Islet Autoimmunity and Type 1 Diabetes : The Diabetes Autoimmunity Study in the Young. Clinical and Developmental Immunology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-470561
American Medical Association (AMA)
Frederiksen, Brittni N.& Steck, Andrea K.& Kroehl, Miranda& Lamb, Molly M.& Wong, Randall& Rewers, Marian…[et al.]. Evidence of Stage- and Age-Related Heterogeneity of Non-HLA SNPs and Risk of Islet Autoimmunity and Type 1 Diabetes : The Diabetes Autoimmunity Study in the Young. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470561