Evaluation of the Pattern of EPIYA Motifs in the Helicobacter pylori cagA Gene of Patients with Gastritis and Gastric Adenocarcinoma from the Brazilian Amazon Region
المؤلفون المشاركون
da Costa, Renata Aparecida Andrade
Fecury, Amanda Alves
Quaresma, Juarez Antônio Simões
Junior, Mario Ribeiro da Silva
Vinagre, Ruth Maria Dias Ferreira
Martins, Luisa Caricio
Vilar e Silva, Adenielson
Santos, Kemper Nunes
المصدر
International Journal of Bacteriology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The Helicobacter pylori is associated with the development of different diseases.
The clinical outcome of infection may be associated with the cagA bacterial genotype.
The aim of this study was to determine the EPIYA patterns of strains isolated from patients with gastritis and gastric adenocarcinoma and correlate these patterns with the histopathological features.
Gastric biopsy samples were selected from 384 patients infected with H.
pylori, including 194 with chronic gastritis and 190 with gastric adenocarcinoma.
The presence of the cagA gene and the EPIYA motif was determined by PCR.
The cagA gene was more prevalent in patients with gastric cancer and was associated with a higher degree of inflammation, neutrophil activity, and development of intestinal metaplasia.
The number of EPIYA-C repeats showed a significant association with an increased risk of gastric carcinoma (OR = 3.79, 95% CI = 1.92–7.46, and P=0.002).
A larger number of EPIYA-C motifs were also associated with intestinal metaplasia.
In the present study, infection with H.
pylori strains harboring more than one EPIYA-C motif in the cagA gene was associated with the development of intestinal metaplasia and gastric adenocarcinoma but not with neutrophil activity or degree of inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vilar e Silva, Adenielson& Junior, Mario Ribeiro da Silva& Vinagre, Ruth Maria Dias Ferreira& Santos, Kemper Nunes& da Costa, Renata Aparecida Andrade& Fecury, Amanda Alves…[et al.]. 2014. Evaluation of the Pattern of EPIYA Motifs in the Helicobacter pylori cagA Gene of Patients with Gastritis and Gastric Adenocarcinoma from the Brazilian Amazon Region. International Journal of Bacteriology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470603
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vilar e Silva, Adenielson…[et al.]. Evaluation of the Pattern of EPIYA Motifs in the Helicobacter pylori cagA Gene of Patients with Gastritis and Gastric Adenocarcinoma from the Brazilian Amazon Region. International Journal of Bacteriology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-470603
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vilar e Silva, Adenielson& Junior, Mario Ribeiro da Silva& Vinagre, Ruth Maria Dias Ferreira& Santos, Kemper Nunes& da Costa, Renata Aparecida Andrade& Fecury, Amanda Alves…[et al.]. Evaluation of the Pattern of EPIYA Motifs in the Helicobacter pylori cagA Gene of Patients with Gastritis and Gastric Adenocarcinoma from the Brazilian Amazon Region. International Journal of Bacteriology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470603
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470603
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر