The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF)
المؤلفون المشاركون
Zamboni, Dario S.
Hori, Juliana I.
Berretta, Andresa Aparecida
Goldman, Gustavo Henrique
Carrão, Daniel B.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-16
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Propolis extracts have gained the attention of consumers and researchers due to their unique chemical compositions and functional properties such as its anti-inflammatory activity.
Recently, it was described a complex that is also important in inflammatory processes, named inflammasome.
The inflammasomes are a large molecular platform formed in the cell cytosol in response to stress signals, toxins, and microbial infections.
Once activated, the inflammasome induces caspase-1, which in turn induces the processing of inflammatory cytokines such as IL-1β and IL-18.
So, to understand inflammasomes regulation becomes crucial to treat several disorders including autoinflammatory diseases.
Since green propolis extracts are able to regulate inflammatory pathways, this work purpose was to investigate if this extract could also act on inflammasomes regulation.
First, the extract was characterized and it demonstrated the presence of important compounds, especially Artepillin C.
This extract was effective in reducing the IL-1β secretion in mouse macrophages and this reduction was correlated with a decrease in activation of the protease caspase-1.
Furthermore, we found that the extract at a concentration of 30 μg/mL was not toxic to the cells even after a 18-hour treatment.
Altogether, these data indicate that Brazilian green propolis (EPP-AF) extract has a role in regulating the inflammasomes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hori, Juliana I.& Zamboni, Dario S.& Carrão, Daniel B.& Goldman, Gustavo Henrique& Berretta, Andresa Aparecida. 2013. The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF). Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-470646
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hori, Juliana I.…[et al.]. The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF). Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-470646
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hori, Juliana I.& Zamboni, Dario S.& Carrão, Daniel B.& Goldman, Gustavo Henrique& Berretta, Andresa Aparecida. The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF). Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-470646
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470646
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر