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The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF)
Joint Authors
Zamboni, Dario S.
Hori, Juliana I.
Berretta, Andresa Aparecida
Goldman, Gustavo Henrique
Carrão, Daniel B.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Propolis extracts have gained the attention of consumers and researchers due to their unique chemical compositions and functional properties such as its anti-inflammatory activity.
Recently, it was described a complex that is also important in inflammatory processes, named inflammasome.
The inflammasomes are a large molecular platform formed in the cell cytosol in response to stress signals, toxins, and microbial infections.
Once activated, the inflammasome induces caspase-1, which in turn induces the processing of inflammatory cytokines such as IL-1β and IL-18.
So, to understand inflammasomes regulation becomes crucial to treat several disorders including autoinflammatory diseases.
Since green propolis extracts are able to regulate inflammatory pathways, this work purpose was to investigate if this extract could also act on inflammasomes regulation.
First, the extract was characterized and it demonstrated the presence of important compounds, especially Artepillin C.
This extract was effective in reducing the IL-1β secretion in mouse macrophages and this reduction was correlated with a decrease in activation of the protease caspase-1.
Furthermore, we found that the extract at a concentration of 30 μg/mL was not toxic to the cells even after a 18-hour treatment.
Altogether, these data indicate that Brazilian green propolis (EPP-AF) extract has a role in regulating the inflammasomes.
American Psychological Association (APA)
Hori, Juliana I.& Zamboni, Dario S.& Carrão, Daniel B.& Goldman, Gustavo Henrique& Berretta, Andresa Aparecida. 2013. The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF). Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-470646
Modern Language Association (MLA)
Hori, Juliana I.…[et al.]. The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF). Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-470646
American Medical Association (AMA)
Hori, Juliana I.& Zamboni, Dario S.& Carrão, Daniel B.& Goldman, Gustavo Henrique& Berretta, Andresa Aparecida. The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF). Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-470646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470646