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Systemic Approach to Identify Serum microRNAs as Potential Biomarkers for Acute Myocardial Infarction
المؤلفون المشاركون
Chang, Yu-Sun
Chen, Shu-Jen
Chen, Hua-Chien
Chu, Pao-Hsien
Hsu, An
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-12
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Recent studies have revealed the role of microRNAs (miRNAs) in a variety of biological and pathological processes, including acute myocardial infarction (AMI).
We hypothesized that ST-segment elevation myocardial infarction (STEMI) may be associated with an alteration of miRNAs and that circulating miRNAs may be used as diagnostic markers for STEMI.
Methods.
Expression levels of 270 serum miRNAs were analyzed in 8 STEMI patients and 8 matched healthy controls to identify miRNAs differentially expressed in the sera of patients with AMI.
The differentially expressed miRNAs were evaluated in a separate cohort of 62 subjects, including 31 STEMI patients and 31 normal controls.
Results.
The initial profiling study identified 12 upregulated and 13 downregulated serum miRNAs in the AMI samples.
A subsequent validation study confirmed that serum miR-486-3p and miR-150-3p were upregulated while miR-126-3p, miR-26a-5p, and miR-191-5p were significantly downregulated in the sera of patients with AMI.
Ratios between the level of upregulated and downregulated miRNAs were also significantly different in those with AMI.
Receiver operator characteristics curve analysis using the expression ratio of miR-486-3p and miR-191-5p showed an area under the curve of 0.863.
Conclusion.
Our results suggest that serum miRNAs may be used as potential diagnostic biomarkers for STEMI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hsu, An& Chen, Shu-Jen& Chang, Yu-Sun& Chen, Hua-Chien& Chu, Pao-Hsien. 2014. Systemic Approach to Identify Serum microRNAs as Potential Biomarkers for Acute Myocardial Infarction. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-470662
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hsu, An…[et al.]. Systemic Approach to Identify Serum microRNAs as Potential Biomarkers for Acute Myocardial Infarction. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-470662
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hsu, An& Chen, Shu-Jen& Chang, Yu-Sun& Chen, Hua-Chien& Chu, Pao-Hsien. Systemic Approach to Identify Serum microRNAs as Potential Biomarkers for Acute Myocardial Infarction. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-470662
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470662
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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