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Systemic Approach to Identify Serum microRNAs as Potential Biomarkers for Acute Myocardial Infarction
Joint Authors
Chang, Yu-Sun
Chen, Shu-Jen
Chen, Hua-Chien
Chu, Pao-Hsien
Hsu, An
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Recent studies have revealed the role of microRNAs (miRNAs) in a variety of biological and pathological processes, including acute myocardial infarction (AMI).
We hypothesized that ST-segment elevation myocardial infarction (STEMI) may be associated with an alteration of miRNAs and that circulating miRNAs may be used as diagnostic markers for STEMI.
Methods.
Expression levels of 270 serum miRNAs were analyzed in 8 STEMI patients and 8 matched healthy controls to identify miRNAs differentially expressed in the sera of patients with AMI.
The differentially expressed miRNAs were evaluated in a separate cohort of 62 subjects, including 31 STEMI patients and 31 normal controls.
Results.
The initial profiling study identified 12 upregulated and 13 downregulated serum miRNAs in the AMI samples.
A subsequent validation study confirmed that serum miR-486-3p and miR-150-3p were upregulated while miR-126-3p, miR-26a-5p, and miR-191-5p were significantly downregulated in the sera of patients with AMI.
Ratios between the level of upregulated and downregulated miRNAs were also significantly different in those with AMI.
Receiver operator characteristics curve analysis using the expression ratio of miR-486-3p and miR-191-5p showed an area under the curve of 0.863.
Conclusion.
Our results suggest that serum miRNAs may be used as potential diagnostic biomarkers for STEMI.
American Psychological Association (APA)
Hsu, An& Chen, Shu-Jen& Chang, Yu-Sun& Chen, Hua-Chien& Chu, Pao-Hsien. 2014. Systemic Approach to Identify Serum microRNAs as Potential Biomarkers for Acute Myocardial Infarction. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-470662
Modern Language Association (MLA)
Hsu, An…[et al.]. Systemic Approach to Identify Serum microRNAs as Potential Biomarkers for Acute Myocardial Infarction. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-470662
American Medical Association (AMA)
Hsu, An& Chen, Shu-Jen& Chang, Yu-Sun& Chen, Hua-Chien& Chu, Pao-Hsien. Systemic Approach to Identify Serum microRNAs as Potential Biomarkers for Acute Myocardial Infarction. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-470662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470662