Experimental Evaluation of Ethanolic Extract of Carapa guianensis L. Leaf for Its Wound Healing Activity Using Three Wound Models
المؤلفون المشاركون
Pereira, Lexley Pinto
Kanhai, Joel
Nayak, B. Shivananda
Swanston, William H.
Milne, David Malcolm
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-17
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The leaves of Carapa guianensis have been used to treat ulcers, skin parasites, and skin problems.
The ethanolic extract of C.
guianensis leaf was evaluated for its antibacterial and wound healing activity using excision, incision and dead space wound models in rats.
The animals were randomly divided into two groups (n = 6) in all the models.
In the excision wound model test group animals were treated topically with the leaf extract (250 mg kg−1 body weight) whereas, control animals were treated with petroleum jelly.
In the incision and dead space wound models, the test group animals were treated with extract (250 mg kg−1 day−1) orally by mixing in drinking water and the control group animals were maintained with plain drinking water.
Healing was assessed by the rate of wound contraction, period of epithelialization, skin breaking strength, granulation tissue weight and hydoxyproline content.
On Day 15 extract-treated animals exhibited 100% reduction in the wound area when compared to controls (95%) with significant decrease in the epithelialization period.
The extract failed to demonstrate antibacterial activity.
Skin breaking strength (P < .001), wet (P < .002) and dry (P < .02) granulation tissue and hydroxyproline content (P < .03) were significantly higher in extract treated animals.
The increased rate of wound contraction, skin breaking strength and hydroxyproline content supports potential application of C.
guianensis in wound healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nayak, B. Shivananda& Kanhai, Joel& Milne, David Malcolm& Pereira, Lexley Pinto& Swanston, William H.. 2011. Experimental Evaluation of Ethanolic Extract of Carapa guianensis L. Leaf for Its Wound Healing Activity Using Three Wound Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-470759
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nayak, B. Shivananda…[et al.]. Experimental Evaluation of Ethanolic Extract of Carapa guianensis L. Leaf for Its Wound Healing Activity Using Three Wound Models. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-470759
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nayak, B. Shivananda& Kanhai, Joel& Milne, David Malcolm& Pereira, Lexley Pinto& Swanston, William H.. Experimental Evaluation of Ethanolic Extract of Carapa guianensis L. Leaf for Its Wound Healing Activity Using Three Wound Models. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-470759
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470759
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر