Experimental Evaluation of Ethanolic Extract of Carapa guianensis L. Leaf for Its Wound Healing Activity Using Three Wound Models
Joint Authors
Pereira, Lexley Pinto
Kanhai, Joel
Nayak, B. Shivananda
Swanston, William H.
Milne, David Malcolm
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The leaves of Carapa guianensis have been used to treat ulcers, skin parasites, and skin problems.
The ethanolic extract of C.
guianensis leaf was evaluated for its antibacterial and wound healing activity using excision, incision and dead space wound models in rats.
The animals were randomly divided into two groups (n = 6) in all the models.
In the excision wound model test group animals were treated topically with the leaf extract (250 mg kg−1 body weight) whereas, control animals were treated with petroleum jelly.
In the incision and dead space wound models, the test group animals were treated with extract (250 mg kg−1 day−1) orally by mixing in drinking water and the control group animals were maintained with plain drinking water.
Healing was assessed by the rate of wound contraction, period of epithelialization, skin breaking strength, granulation tissue weight and hydoxyproline content.
On Day 15 extract-treated animals exhibited 100% reduction in the wound area when compared to controls (95%) with significant decrease in the epithelialization period.
The extract failed to demonstrate antibacterial activity.
Skin breaking strength (P < .001), wet (P < .002) and dry (P < .02) granulation tissue and hydroxyproline content (P < .03) were significantly higher in extract treated animals.
The increased rate of wound contraction, skin breaking strength and hydroxyproline content supports potential application of C.
guianensis in wound healing.
American Psychological Association (APA)
Nayak, B. Shivananda& Kanhai, Joel& Milne, David Malcolm& Pereira, Lexley Pinto& Swanston, William H.. 2011. Experimental Evaluation of Ethanolic Extract of Carapa guianensis L. Leaf for Its Wound Healing Activity Using Three Wound Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-470759
Modern Language Association (MLA)
Nayak, B. Shivananda…[et al.]. Experimental Evaluation of Ethanolic Extract of Carapa guianensis L. Leaf for Its Wound Healing Activity Using Three Wound Models. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-470759
American Medical Association (AMA)
Nayak, B. Shivananda& Kanhai, Joel& Milne, David Malcolm& Pereira, Lexley Pinto& Swanston, William H.. Experimental Evaluation of Ethanolic Extract of Carapa guianensis L. Leaf for Its Wound Healing Activity Using Three Wound Models. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-470759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470759