Amelioratory Effect of Nanoconjugated Vancomycin on Spleen during VRSA-Induced Oxidative Stress
المؤلفون المشاركون
Roy, Somenath
Chakraborty, Subhankari Prasad
Sahu, Sumanta Kumar
Pramanik, Panchanan
Kar Mahapatra, Santanu
المصدر
Pathology Research International
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
The aim of the present study was to evaluate the possible antioxidant effects of nanoconjugated vancomycin against VRSA infection on select makers of oxidative damage and antioxidant status in spleen.
Methods.
A coagulase-positive VRSA strain was used for this study.
VRSA infection was developed in Swiss mice by intraperitoneal injection of 5 × 106 CFU/mL bacterial solutions.
VRSA-infected mice were treated with nanoconjugated vancomycin at its effective dose for 10 days.
After decapitation, blood was used for determination of viable bacteria count and spleen was excised from control and experimental groups, homogenized and used for different biochemical estimations.
Results.
Nitrate level, myeloperoxidase activity, lipid peroxidation, protein oxidation, oxidized glutathione, and DNA fragmentation level were increased significantly (P<0.05) in spleen of VRSA-infected group as compared to control group, and reduced glutathione level, activity of SOD, CAT, GPx, GR, and GST were decreased significantly (P<0.05); which were increased or decreased significantly (P<0.05) near to normal in nanoconjugated vancomycin-treated group.
Conclusion.
These findings suggest the potential use and beneficial role of nanoconjugated vancomycin against VRSA-infection-induced oxidative stress and DNA damage in spleen.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chakraborty, Subhankari Prasad& Kar Mahapatra, Santanu& Sahu, Sumanta Kumar& Pramanik, Panchanan& Roy, Somenath. 2011. Amelioratory Effect of Nanoconjugated Vancomycin on Spleen during VRSA-Induced Oxidative Stress. Pathology Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-470802
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chakraborty, Subhankari Prasad…[et al.]. Amelioratory Effect of Nanoconjugated Vancomycin on Spleen during VRSA-Induced Oxidative Stress. Pathology Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-470802
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chakraborty, Subhankari Prasad& Kar Mahapatra, Santanu& Sahu, Sumanta Kumar& Pramanik, Panchanan& Roy, Somenath. Amelioratory Effect of Nanoconjugated Vancomycin on Spleen during VRSA-Induced Oxidative Stress. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-470802
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470802
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر