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Amelioratory Effect of Nanoconjugated Vancomycin on Spleen during VRSA-Induced Oxidative Stress
Joint Authors
Roy, Somenath
Chakraborty, Subhankari Prasad
Sahu, Sumanta Kumar
Pramanik, Panchanan
Kar Mahapatra, Santanu
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
The aim of the present study was to evaluate the possible antioxidant effects of nanoconjugated vancomycin against VRSA infection on select makers of oxidative damage and antioxidant status in spleen.
Methods.
A coagulase-positive VRSA strain was used for this study.
VRSA infection was developed in Swiss mice by intraperitoneal injection of 5 × 106 CFU/mL bacterial solutions.
VRSA-infected mice were treated with nanoconjugated vancomycin at its effective dose for 10 days.
After decapitation, blood was used for determination of viable bacteria count and spleen was excised from control and experimental groups, homogenized and used for different biochemical estimations.
Results.
Nitrate level, myeloperoxidase activity, lipid peroxidation, protein oxidation, oxidized glutathione, and DNA fragmentation level were increased significantly (P<0.05) in spleen of VRSA-infected group as compared to control group, and reduced glutathione level, activity of SOD, CAT, GPx, GR, and GST were decreased significantly (P<0.05); which were increased or decreased significantly (P<0.05) near to normal in nanoconjugated vancomycin-treated group.
Conclusion.
These findings suggest the potential use and beneficial role of nanoconjugated vancomycin against VRSA-infection-induced oxidative stress and DNA damage in spleen.
American Psychological Association (APA)
Chakraborty, Subhankari Prasad& Kar Mahapatra, Santanu& Sahu, Sumanta Kumar& Pramanik, Panchanan& Roy, Somenath. 2011. Amelioratory Effect of Nanoconjugated Vancomycin on Spleen during VRSA-Induced Oxidative Stress. Pathology Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-470802
Modern Language Association (MLA)
Chakraborty, Subhankari Prasad…[et al.]. Amelioratory Effect of Nanoconjugated Vancomycin on Spleen during VRSA-Induced Oxidative Stress. Pathology Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-470802
American Medical Association (AMA)
Chakraborty, Subhankari Prasad& Kar Mahapatra, Santanu& Sahu, Sumanta Kumar& Pramanik, Panchanan& Roy, Somenath. Amelioratory Effect of Nanoconjugated Vancomycin on Spleen during VRSA-Induced Oxidative Stress. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-470802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470802