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Equine Arteritis Virus Does Not Induce Interferon Production in Equine Endothelial Cells : Identification of Nonstructural Protein 1 as a Main Interferon Antagonist
المؤلفون المشاركون
Chen, Zhenhai
Yoo, Dongwan
Fang, Ying
Balasuriya, Udeni B. R.
Li, Yanhua
Go, Yun Young
Han, Mingyuan
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-25
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The objective of this study was to investigate the effect of equine arteritis virus (EAV) on type I interferon (IFN) production.
Equine endothelial cells (EECs) were infected with the virulent Bucyrus strain (VBS) of EAV and expression of IFN-β was measured at mRNA and protein levels by quantitative real-time RT-PCR and IFN bioassay using vesicular stomatitis virus expressing the green fluorescence protein (VSV-GFP), respectively.
Quantitative RT-PCR results showed that IFN-β mRNA levels in EECs infected with EAV VBS were not increased compared to those in mock-infected cells.
Consistent with quantitative RT-PCR, Sendai virus- (SeV-) induced type I IFN production was inhibited by EAV infection.
Using an IFN-β promoter-luciferase reporter assay, we subsequently demonstrated that EAV nsps 1, 2, and 11 had the capability to inhibit type I IFN activation.
Of these three nsps, nsp1 exhibited the strongest inhibitory effect.
Taken together, these data demonstrate that EAV has the ability to suppress the type I IFN production in EECs and nsp1 may play a critical role to subvert the equine innate immune response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Go, Yun Young& Li, Yanhua& Chen, Zhenhai& Han, Mingyuan& Yoo, Dongwan& Fang, Ying…[et al.]. 2014. Equine Arteritis Virus Does Not Induce Interferon Production in Equine Endothelial Cells : Identification of Nonstructural Protein 1 as a Main Interferon Antagonist. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-470843
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Go, Yun Young…[et al.]. Equine Arteritis Virus Does Not Induce Interferon Production in Equine Endothelial Cells : Identification of Nonstructural Protein 1 as a Main Interferon Antagonist. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-470843
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Go, Yun Young& Li, Yanhua& Chen, Zhenhai& Han, Mingyuan& Yoo, Dongwan& Fang, Ying…[et al.]. Equine Arteritis Virus Does Not Induce Interferon Production in Equine Endothelial Cells : Identification of Nonstructural Protein 1 as a Main Interferon Antagonist. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-470843
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470843
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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