![](/images/graphics-bg.png)
Complement C3 Genotype Variants and Risk of Lung Cancer Mortality
المؤلفون المشاركون
Hein, Hans Ole
Suadicani, Poul
Gyntelberg, Finn
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-07
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Inflammation and genetic susceptibility influence the risk of lung cancer.
During recent years, the role of complement as a part of the humoral response has advanced from being considered complementary to being regarded as a central element in innate immunity.
C3 complement allotypes F and S have been associated with a number of inflammatory diseases.
The C3F allele frequency is approximately 20% in Caucasian populations and the C3S approximately 80%, resulting in the three predominant genotypes FF (4%), FS (32%), and SS (64%).
To our knowledge, no studies have investigated if different C3 allotypes or genotypes predict the risk of lung cancer.
We tested in a long-term followup of 3,197 men aged 53 to 74 years the hypothesis that risk of lung cancer would depend on C3 complement genotypes.
During 16 years, 160 subjects (5.0%) died from lung cancer, 68 men (6.1%) among complement C3 genotypes FS/FF, and 92 men (4.4%) among genotype SS; age-adjusted hazard ratio with 95%CI (HR) was 1.42 (1.04–1.94) and strongest, 2.71 (1.34–5.45), among the oldest fifth.
C3 complement genotype variants were significantly associated with lung cancer mortality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Suadicani, Poul& Hein, Hans Ole& Gyntelberg, Finn. 2011. Complement C3 Genotype Variants and Risk of Lung Cancer Mortality. ISRN Pulmonology،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-471013
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Suadicani, Poul…[et al.]. Complement C3 Genotype Variants and Risk of Lung Cancer Mortality. ISRN Pulmonology No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-471013
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Suadicani, Poul& Hein, Hans Ole& Gyntelberg, Finn. Complement C3 Genotype Variants and Risk of Lung Cancer Mortality. ISRN Pulmonology. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-471013
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471013
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)