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Complement C3 Genotype Variants and Risk of Lung Cancer Mortality
Joint Authors
Hein, Hans Ole
Suadicani, Poul
Gyntelberg, Finn
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Inflammation and genetic susceptibility influence the risk of lung cancer.
During recent years, the role of complement as a part of the humoral response has advanced from being considered complementary to being regarded as a central element in innate immunity.
C3 complement allotypes F and S have been associated with a number of inflammatory diseases.
The C3F allele frequency is approximately 20% in Caucasian populations and the C3S approximately 80%, resulting in the three predominant genotypes FF (4%), FS (32%), and SS (64%).
To our knowledge, no studies have investigated if different C3 allotypes or genotypes predict the risk of lung cancer.
We tested in a long-term followup of 3,197 men aged 53 to 74 years the hypothesis that risk of lung cancer would depend on C3 complement genotypes.
During 16 years, 160 subjects (5.0%) died from lung cancer, 68 men (6.1%) among complement C3 genotypes FS/FF, and 92 men (4.4%) among genotype SS; age-adjusted hazard ratio with 95%CI (HR) was 1.42 (1.04–1.94) and strongest, 2.71 (1.34–5.45), among the oldest fifth.
C3 complement genotype variants were significantly associated with lung cancer mortality.
American Psychological Association (APA)
Suadicani, Poul& Hein, Hans Ole& Gyntelberg, Finn. 2011. Complement C3 Genotype Variants and Risk of Lung Cancer Mortality. ISRN Pulmonology،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-471013
Modern Language Association (MLA)
Suadicani, Poul…[et al.]. Complement C3 Genotype Variants and Risk of Lung Cancer Mortality. ISRN Pulmonology No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-471013
American Medical Association (AMA)
Suadicani, Poul& Hein, Hans Ole& Gyntelberg, Finn. Complement C3 Genotype Variants and Risk of Lung Cancer Mortality. ISRN Pulmonology. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-471013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471013