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The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions : A Pilot Experiment
المؤلفون المشاركون
Bischoff, Stephan C.
Ritze, Yvonne
Siegle, Stefanie
Otto, Bärbel
Rieber, Nicole
Mack, Isabelle
Sauer, Helene
Kohler, Silke
Enck, Paul
Zipfel, Stephan
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Fat affects gastric emptying (GE).
5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms.
Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated.
Subjects/Methods.
24 healthy individuals (12f : 12m, 22–29 years, BMI 19–25.7 kg/m²) were tested on 4 days with either 5-HTP + short-chain saturated FA (butter), placebo + butter, 5-HTP + monounsaturated FA (olive oil), or placebo + olive oil in double-blinded randomized order.
Two hours after FA/5-HTP or placebo intake, a 13C octanoid acid test was conducted.
Cortisol, serotonin, cholecystokinin (CCK), and ghrelin were measured, as were mood and GE.
Results.
GE was delayed with butter and was normal with olive (P<0.05) but not affected by 5-HTP.
5-HTP supplementation did not affect serotonin levels.
Food intake increased plasma CCK (F=6.136; P<0.05) irrespective of the FA.
Ghrelin levels significantly decreased with oil/5-HTP (F=9.166; P<0.001).
The diurnal cortisol profile was unaffected by FA or 5-HTP, as were ratings of mood, hunger, and stool urgency.
Conclusion.
Diverse FAs have different effects on GE and secretion of orexigenic and anorexigenic hormones.
Supplementation of 5-HTP had no effect on plasma serotonin and central functions.
Further studies are needed to explain the complex interplay.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sauer, Helene& Mack, Isabelle& Kohler, Silke& Siegle, Stefanie& Rieber, Nicole& Zipfel, Stephan…[et al.]. 2014. The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions : A Pilot Experiment. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471095
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sauer, Helene…[et al.]. The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions : A Pilot Experiment. Gastroenterology Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-471095
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sauer, Helene& Mack, Isabelle& Kohler, Silke& Siegle, Stefanie& Rieber, Nicole& Zipfel, Stephan…[et al.]. The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions : A Pilot Experiment. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471095
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471095
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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