The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions : A Pilot Experiment
Joint Authors
Bischoff, Stephan C.
Ritze, Yvonne
Siegle, Stefanie
Otto, Bärbel
Rieber, Nicole
Mack, Isabelle
Sauer, Helene
Kohler, Silke
Enck, Paul
Zipfel, Stephan
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Fat affects gastric emptying (GE).
5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms.
Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated.
Subjects/Methods.
24 healthy individuals (12f : 12m, 22–29 years, BMI 19–25.7 kg/m²) were tested on 4 days with either 5-HTP + short-chain saturated FA (butter), placebo + butter, 5-HTP + monounsaturated FA (olive oil), or placebo + olive oil in double-blinded randomized order.
Two hours after FA/5-HTP or placebo intake, a 13C octanoid acid test was conducted.
Cortisol, serotonin, cholecystokinin (CCK), and ghrelin were measured, as were mood and GE.
Results.
GE was delayed with butter and was normal with olive (P<0.05) but not affected by 5-HTP.
5-HTP supplementation did not affect serotonin levels.
Food intake increased plasma CCK (F=6.136; P<0.05) irrespective of the FA.
Ghrelin levels significantly decreased with oil/5-HTP (F=9.166; P<0.001).
The diurnal cortisol profile was unaffected by FA or 5-HTP, as were ratings of mood, hunger, and stool urgency.
Conclusion.
Diverse FAs have different effects on GE and secretion of orexigenic and anorexigenic hormones.
Supplementation of 5-HTP had no effect on plasma serotonin and central functions.
Further studies are needed to explain the complex interplay.
American Psychological Association (APA)
Sauer, Helene& Mack, Isabelle& Kohler, Silke& Siegle, Stefanie& Rieber, Nicole& Zipfel, Stephan…[et al.]. 2014. The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions : A Pilot Experiment. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471095
Modern Language Association (MLA)
Sauer, Helene…[et al.]. The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions : A Pilot Experiment. Gastroenterology Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-471095
American Medical Association (AMA)
Sauer, Helene& Mack, Isabelle& Kohler, Silke& Siegle, Stefanie& Rieber, Nicole& Zipfel, Stephan…[et al.]. The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions : A Pilot Experiment. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471095