A Study on Course of Infection and Haematological Changes in falciparum-Infected in Comparison with Artemisinin(s)-Treated Mice
المؤلفون المشاركون
Meka, Sowjanya
Kanikaram, Sunita
Kuthala, Kalyan Kumar
المصدر
Malaria Research and Treatment
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
To find out the efficacy and effect of artemisinin derivatives on haematological indices, C57BL/6J mice were challenged with Plasmodium falciparum and treated with therapeutic doses of AS, AE, and AL.
Course of infection was studied in the infected and treated groups up to day 42.
Peak level of parasitaemia (38%) was observed on day 11 in infected group.
Haematological indices indicated significant (P<0.05) decrease in RBC, WBC, haemoglobin, packed cell volume, mean cell volume, and platelet counts in infected mice.
But all the parameters were restored to normal values, and significant (P<0.05) changes were observed in all drug-treated groups.
Insignificant changes were observed for MCHC (P>0.05) in all drug-treated groups.
Percent of peak parasitaemia was much reduced in AL- (3.2% on day 3) treated group in comparison with AE- (2.4% on day 4) and AS- (4% on day 2) treated groups.
Parasites were completely cleared on day 6 in AS group, day 5 in AE group, and day 4 in AL group.
Hence, our results strongly support that combination therapy has high efficacy rates than monotherapy.
No adverse effects were observed on haematological parameters when animals were treated with therapeutic dosages.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kuthala, Kalyan Kumar& Meka, Sowjanya& Kanikaram, Sunita. 2013. A Study on Course of Infection and Haematological Changes in falciparum-Infected in Comparison with Artemisinin(s)-Treated Mice. Malaria Research and Treatment،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-471237
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kuthala, Kalyan Kumar…[et al.]. A Study on Course of Infection and Haematological Changes in falciparum-Infected in Comparison with Artemisinin(s)-Treated Mice. Malaria Research and Treatment No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-471237
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kuthala, Kalyan Kumar& Meka, Sowjanya& Kanikaram, Sunita. A Study on Course of Infection and Haematological Changes in falciparum-Infected in Comparison with Artemisinin(s)-Treated Mice. Malaria Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-471237
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471237
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر