![](/images/graphics-bg.png)
A Study on Course of Infection and Haematological Changes in falciparum-Infected in Comparison with Artemisinin(s)-Treated Mice
Joint Authors
Meka, Sowjanya
Kanikaram, Sunita
Kuthala, Kalyan Kumar
Source
Malaria Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
To find out the efficacy and effect of artemisinin derivatives on haematological indices, C57BL/6J mice were challenged with Plasmodium falciparum and treated with therapeutic doses of AS, AE, and AL.
Course of infection was studied in the infected and treated groups up to day 42.
Peak level of parasitaemia (38%) was observed on day 11 in infected group.
Haematological indices indicated significant (P<0.05) decrease in RBC, WBC, haemoglobin, packed cell volume, mean cell volume, and platelet counts in infected mice.
But all the parameters were restored to normal values, and significant (P<0.05) changes were observed in all drug-treated groups.
Insignificant changes were observed for MCHC (P>0.05) in all drug-treated groups.
Percent of peak parasitaemia was much reduced in AL- (3.2% on day 3) treated group in comparison with AE- (2.4% on day 4) and AS- (4% on day 2) treated groups.
Parasites were completely cleared on day 6 in AS group, day 5 in AE group, and day 4 in AL group.
Hence, our results strongly support that combination therapy has high efficacy rates than monotherapy.
No adverse effects were observed on haematological parameters when animals were treated with therapeutic dosages.
American Psychological Association (APA)
Kuthala, Kalyan Kumar& Meka, Sowjanya& Kanikaram, Sunita. 2013. A Study on Course of Infection and Haematological Changes in falciparum-Infected in Comparison with Artemisinin(s)-Treated Mice. Malaria Research and Treatment،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-471237
Modern Language Association (MLA)
Kuthala, Kalyan Kumar…[et al.]. A Study on Course of Infection and Haematological Changes in falciparum-Infected in Comparison with Artemisinin(s)-Treated Mice. Malaria Research and Treatment No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-471237
American Medical Association (AMA)
Kuthala, Kalyan Kumar& Meka, Sowjanya& Kanikaram, Sunita. A Study on Course of Infection and Haematological Changes in falciparum-Infected in Comparison with Artemisinin(s)-Treated Mice. Malaria Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-471237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471237